水素水摂取によるパラコート誘発急性肺障害の軽減：ラットを用いた検討
This study examined whether hydrogen-rich water consumption could protect rats from acute lung injury induced by paraquat. Adult male Sprague-Dawley rats were divided into four groups: control, hydrogen water only, paraquat only (35 mg/kg intraperitoneally), and paraquat plus hydrogen water. Biochemical and histological parameters of lung injury were assessed. Rats receiving hydrogen water alongside paraquat showed marked improvement in both biochemical and histological lung alterations compared with the paraquat-only group. The findings suggest that suppression of oxidative damage is a key mechanism underlying the protective effect of hydrogen-rich water against paraquat-induced acute lung injury.
Dissolved molecular hydrogen is proposed to scavenge reactive oxygen species, thereby suppressing oxidative damage and attenuating the biochemical and histological lung alterations caused by paraquat exposure.
Hydrogen-rich water is a low-risk delivery route, but the achievable systemic hydrogen dose is bounded. For clinical applications, inhalation is the most efficient route; inhalation, however, carries explosion risk, and concentration matters (empirical LFL of 10% applies to inhalation environments; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).
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https://h2-papers.org/en/papers/21318114