双極性障害および統合失調症における分子状水素の神経生物学的作用と応用可能性の概説
Molecular hydrogen (H2) is a biologically active molecule exhibiting anti-apoptotic, anti-inflammatory, and antioxidant properties. These characteristics align with the pathophysiological mechanisms underlying neuroprogression observed in major psychiatric conditions. Both bipolar disorder and schizophrenia are characterized by elevated oxidative and inflammatory stress. Notably, mood stabilizers such as lithium and valproate, as well as certain atypical antipsychotics, are known to modulate oxidative stress and apoptotic signaling. Preclinical animal studies have examined H2 in contexts such as hypoxia and neurodegeneration, and clinical observations in Parkinson's disease have yielded encouraging results. Based on this convergence of evidence, the authors propose that H2 administration warrants investigation as a novel approach for bipolar disorder, schizophrenia, and related conditions involving dysregulation of oxidative, inflammatory, and apoptotic pathways.
H2 is proposed to selectively scavenge reactive oxygen species, particularly hydroxyl radicals, while suppressing inflammatory signaling cascades and apoptotic pathways, thereby exerting neuroprotective effects relevant to psychiatric neuroprogression.
The delivery route is not clearly identifiable from this paper. For hydrogen intake, inhalation is the most efficient route; inhalation, however, carries explosion risk (empirical LFL of 10%; high-concentration devices are not recommended).
See also:
https://h2-papers.org/en/papers/23742229