溶存水素濃度3.5mg以上の水摂取による血管内皮機能への影響：無作為化対照試験
This randomized controlled trial examined whether drinking water with a dissolved hydrogen concentration of 7 ppm (3.5 mg per 500 mL) could influence vascular endothelial function, assessed via flow-mediated dilation (FMD) of the brachial artery. Participants were randomly assigned to a high-H2 water group (8 males, 8 females) or a placebo group (10 males, 8 females). In the high-H2 group, FMD rose from a baseline of 6.80±1.96% to 7.64±1.68%, whereas the placebo group showed a decline from 8.07±2.41% to 6.87±2.94%. The change in FMD relative to baseline was significantly greater in the high-H2 group (P<0.05). These findings suggest that molecular hydrogen may preserve nitric oxide-dependent vasomotor responses by neutralizing shear stress-induced reactive oxygen species, particularly the hydroxyl radical, thereby supporting endothelial function.
Molecular hydrogen selectively scavenges harmful reactive oxygen species, particularly the hydroxyl radical, thereby preserving nitric oxide bioavailability and maintaining endothelium-dependent vasodilation in conduit arteries.
Hydrogen-rich water is a low-risk delivery route, but the achievable systemic hydrogen dose is bounded. For clinical applications, inhalation is the most efficient route; inhalation, however, carries explosion risk, and concentration matters (empirical LFL of 10% applies to inhalation environments; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).
See also:
https://h2-papers.org/en/papers/25378931