医療応用における分子状水素の抗酸化物質としての優位性：概説
Molecular hydrogen (H2), once considered biologically inert in mammalian systems, was shown to react with highly reactive oxidants including hydroxyl radicals and peroxynitrite within cells. A key advantage of H2 is its selective reactivity: it does not interfere with normal metabolic redox processes or reactive oxygen species signaling, suggesting a low adverse-effect profile. Multiple administration routes have been identified, including gas inhalation, oral intake of H2-dissolved water, intravenous or intraperitoneal H2-dissolved saline, bathing, and ocular application. H2 diffuses rapidly across tissues and cellular membranes. Beyond direct scavenging of reactive oxidants, H2 modulates gene expression to exert anti-inflammatory, antiallergic, and antiapoptotic effects, and appears to stimulate energy metabolism. This review summarizes evidence from animal models and clinical investigations supporting the broad potential of H2 across numerous disease contexts.
H2 directly neutralizes hydroxyl radicals and peroxynitrite, and indirectly reduces oxidative stress by modulating gene expression, thereby producing anti-inflammatory, antiallergic, and antiapoptotic effects while also stimulating energy metabolism.
This study combines multiple delivery routes. As a general principle, the most efficient route for routine hydrogen intake is inhalation. Inhalation carries explosion risk (empirical LFL of 10%; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).
See also:
https://h2-papers.org/en/papers/25747486