分子状水素はGHS-R1α活性化を介してミトコンドリアのバイオエネルギー代謝を変化させるか
Since 2007, over 400 original research articles have examined the medical potential of molecular hydrogen (H₂), a gas recognized for its selective antioxidant properties. Beyond its well-documented role in mitigating oxidative stress, emerging evidence points to H₂ involvement in additional mitochondrial functions, particularly metabolic pathways governing cellular energy production. This article explores the hypothesis that H₂ may modulate mitochondrial bioenergetics through activation of the growth hormone secretagogue receptor 1α (GHS-R1α), proposing a mechanistic framework that extends the known biological actions of H₂ beyond reactive oxygen species scavenging.
H₂ is proposed to activate GHS-R1α (the ghrelin receptor), thereby modulating mitochondrial energy metabolism pathways independently of its established reactive oxygen species scavenging activity.
The delivery route is not clearly identifiable from this paper. For hydrogen intake, inhalation is the most efficient route; inhalation, however, carries explosion risk (empirical LFL of 10%; high-concentration devices are not recommended).
See also:
https://h2-papers.org/en/papers/28435468