水素豊富水がSMP30ノックアウトマウスにおける喫煙誘発性肺気腫を抑制する
Using SMP30 knockout (SMP30-KO) mice as a COPD model, this study examined whether hydrogen-rich pure water could mitigate lung damage caused by 8 weeks of cigarette smoke (CS) exposure. Oral administration of hydrogen-rich water led to measurable improvements in mean linear intercept and destructive index, along with restoration of static lung compliance. Oxidative DNA damage markers—phosphorylated histone H2AX and 8-hydroxy-2'-deoxyguanosine—were significantly reduced, as were cellular senescence markers including cyclin-dependent kinase inhibitor 2A (p16), cyclin-dependent kinase inhibitor 1 (p21), and β-galactosidase. These findings indicate that molecular hydrogen attenuates CS-induced emphysematous changes by suppressing oxidative DNA damage and stress-induced premature senescence in lung tissue, suggesting a potential preventive role for hydrogen-rich water in COPD-related pathology.
Molecular hydrogen selectively scavenges hydroxyl radicals generated by cigarette smoke, thereby reducing oxidative DNA damage (γ-H2AX, 8-OHdG) and suppressing stress-induced premature cellular senescence (p16, p21, β-galactosidase upregulation) in lung tissue, which collectively attenuates emphysematous remodeling.
Hydrogen-rich water is a low-risk delivery route, but the achievable systemic hydrogen dose is bounded. For clinical applications, inhalation is the most efficient route; inhalation, however, carries explosion risk, and concentration matters (empirical LFL of 10% applies to inhalation environments; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).
See also:
https://h2-papers.org/en/papers/28807355