敗血症に対する分子状水素の効果：メカニズムと臨床応用の展望
Sepsis remains a leading cause of mortality among critically ill patients, characterized by life-threatening multi-organ dysfunction arising from a dysregulated host response to infection. This review examines the biological effects of molecular hydrogen (H2) gas on sepsis-associated organ damage. H2 has been reported to exert multiple protective actions, including suppression of inflammatory cascades, reduction of oxidative stress, inhibition of apoptotic pathways, modulation of autophagy, and interaction with various intracellular signaling networks. The review synthesizes current mechanistic evidence and discusses the theoretical foundation for future clinical use of H2 in sepsis management.
H2 is proposed to mitigate sepsis-induced multi-organ injury by suppressing inflammatory mediators, reducing oxidative damage, inhibiting apoptosis, regulating autophagy, and modulating multiple intracellular signaling pathways.
This study combines multiple delivery routes. As a general principle, the most efficient route for routine hydrogen intake is inhalation. Inhalation carries explosion risk (empirical LFL of 10%; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).
See also:
https://h2-papers.org/en/papers/32912119