長期水素介入がラットの生理機能に与える影響の検討
This study examined how six months of hydrogen administration affects physiological parameters in healthy rats, comparing hydrogen-rich water (HRW) oral intake with hydrogen inhalation (HI). Body weight and 13 serum biochemical markers were tracked throughout the intervention period. Both delivery methods produced statistically significant changes across the measured parameters. The most pronounced alterations were observed in the serum myocardial enzyme spectrum. Notably, HI produced larger changes in most parameters compared with HRW, and the timing of parameter shifts differed between the two approaches. These findings provide foundational data to support future mechanistic and applied research on molecular hydrogen in normal physiological states.
Both hydrogen inhalation and hydrogen-rich water intake altered multiple serum biochemical parameters in healthy rats, with inhalation producing more pronounced changes, particularly in myocardial enzyme profiles, suggesting route-dependent differences in hydrogen bioavailability or systemic distribution.
This study combines multiple delivery routes. As a general principle, the most efficient route for routine hydrogen intake is inhalation. Inhalation carries explosion risk (empirical LFL of 10%; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).
See also:
https://h2-papers.org/en/papers/33116163