分子状水素の下流シグナル伝達機構に関するレビュー
Molecular hydrogen (H₂) has gained recognition as a small signaling molecule capable of modulating cellular functions. In plant science, hydrogen-rich water (HRW) applied to foliage or root systems has been associated with improvements in growth and productivity. Several mechanistic hypotheses have been proposed to explain H₂ activity: scavenging of hydroxyl radicals, modulation of heme oxygenase activity, and interactions with reactive nitrogen species. Each of these proposed pathways remains contested in the literature. This review critically examines the downstream signaling events potentially governed by H₂, with particular focus on its role in attenuating stress responses in both plant and mammalian systems. The authors aim to identify knowledge gaps and provide a framework to guide future mechanistic investigations.
H₂ is proposed to modulate intracellular signaling via hydroxyl radical scavenging, regulation of heme oxygenase activity, and interaction with reactive nitrogen species; however, the precise downstream pathways remain unresolved.
Hydrogen-rich water is a low-risk delivery route, but the achievable systemic hydrogen dose is bounded. For clinical applications, inhalation is the most efficient route; inhalation, however, carries explosion risk, and concentration matters (empirical LFL of 10% applies to inhalation environments; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).
See also:
https://h2-papers.org/en/papers/33672953