水素水摂取と水素ガス吸入がラットの腸内細菌叢および血漿代謝物に与える異なる影響
This study examined how hydrogen-rich water (HRW) intake and hydrogen gas inhalation (HI) differentially affect gut microbiota and plasma metabolites in healthy rats over a long-term intervention period. Metabolomic profiling identified 14 differential metabolites in the HRW group and 10 in the HI group relative to controls. Pathway analysis indicated that HRW primarily influenced starch and sucrose metabolism, whereas HI was associated with arginine biosynthesis pathways. 16S rRNA gene sequencing revealed that HRW substantially altered gut microbial community structure, notably increasing Lactobacillus, Ruminococcus, and Clostridium XI while reducing Bacteroides. HI was associated with decreased abundances of Blautia and Paraprevotella, without marked overall community shifts. Metabolic cage measurements showed that HI reduced voluntary food and water intake as well as excretion volumes, whereas HRW did not produce such changes. These findings provide foundational data distinguishing the biological effects of two major hydrogen delivery routes on host metabolism and microbiome composition.
HRW appears to modulate gut microbial community structure through starch and sucrose metabolic pathways, while HI exerts its effects primarily via arginine biosynthesis, suggesting route-dependent mechanisms underlying hydrogen's biological actions.
This study combines multiple delivery routes. As a general principle, the most efficient route for routine hydrogen intake is inhalation. Inhalation carries explosion risk (empirical LFL of 10%; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).
See also:
https://h2-papers.org/en/papers/35508571