水素療法の臨床応用：安全性と有効性に関するナラティブレビュー
Molecular hydrogen has attracted growing scientific interest due to its high cellular permeability and biocompatibility. Documented biological effects include suppression of chronic inflammation, reduction of oxidative stress, regulation of apoptosis, and improvement of tissue function. This narrative review examines the efficacy and safety of hydrogen across cardiovascular, respiratory, hematological, metabolic, infectious, and neurodegenerative conditions. Molecular mechanisms underlying these effects and potential nanotechnology-based delivery strategies are also discussed. The authors highlight that current knowledge on formulation, tissue-specific effects, and safety profiles remains limited, and call for large-scale, personalized clinical trials incorporating molecular and genetic biomarkers to advance the field.
Molecular hydrogen selectively scavenges reactive oxygen species, particularly hydroxyl radicals, while suppressing inflammatory signaling cascades and apoptotic pathways, thereby exerting cytoprotective effects across multiple tissue types.
This study combines multiple delivery routes. As a general principle, the most efficient route for routine hydrogen intake is inhalation. Inhalation carries explosion risk (empirical LFL of 10%; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).
See also:
https://h2-papers.org/en/papers/35909288