水素ガス吸入が地域在住の様々な年齢層の成人に与える影響：単群・非盲検・前向き臨床試験
This prospective single-arm study enrolled 54 community-dwelling adults of varying ages to examine the effects of 4-week hydrogen gas inhalation. White blood cell counts (total and differential) remained within normal ranges after the intervention, supporting the safety and tolerability of the protocol. Oxidative stress indicators, specifically reactive oxygen species and nitric oxide, declined following the inhalation period. Dementia-associated biomarkers—including BACE-1, amyloid beta, BDNF, VEGF-A, T-tau, MCP-1, and interleukin-6—showed improvement in the majority of participants, suggesting a beneficial effect on cognitive status. The findings indicate that hydrogen gas inhalation warrants further investigation as a candidate approach for addressing cognitive dysfunction associated with Alzheimer's disease in general adult populations.
Hydrogen gas inhalation appears to reduce reactive oxygen species and nitric oxide levels while modulating Alzheimer's disease-related biomarkers such as BACE-1, amyloid beta, T-tau, and inflammatory cytokines, collectively contributing to improved cognitive function.
For inhalation applications of molecular hydrogen, the lower flammability limit (LFL) deserves careful handling. The classical 4% figure applies to closed-system mixtures; the practical inhalation-environment threshold is 10%. Even pure-hydrogen output (the UFL 75% paradox) passes through the flammable range at the air–gas boundary. High-concentration (66% / 100%) inhalers are documented in the Japanese Consumer Affairs Agency accident-information database and are not recommended.
See also:
https://h2-papers.org/en/papers/37371971