ミトコンドリア生体エネルギー代謝の標的診断と機能改善戦略に関する展望
Elevated oxidative stress and mitochondrial dysfunction underlie the pathogenesis of numerous diseases, including those classified as mitochondrial disorders. Because clinical and metabolic presentations in suspected mitochondrial disease often lack distinguishing features, sensitive diagnostic tools are essential. High-resolution respirometry (HRR) applied to peripheral blood platelets offers a minimally invasive means of detecting subtle alterations in mitochondrial bioenergetics before overt disease onset. Combining HRR with quantification of endogenous coenzyme Q10 (CoQ10) in platelets may facilitate early identification of compromised mitochondrial function and enable monitoring of intervention outcomes. Several strategies aimed at restoring mitochondrial function and reducing oxidative stress are reviewed, including CoQ10 supplementation, molecular hydrogen application, mitochondrial transplantation, and platelet-rich plasma (PRP). This review covers 62 references and discusses the diagnostic and functional implications of these approaches across diverse disease categories.
Molecular hydrogen is proposed to reduce oxidative stress and support mitochondrial bioenergetic function, thereby counteracting pathobiochemical changes associated with mitochondrial dysfunction across various disease states.
The delivery route is not clearly identifiable from this paper. For hydrogen intake, inhalation is the most efficient route; inhalation, however, carries explosion risk (empirical LFL of 10%; high-concentration devices are not recommended).
See also:
https://h2-papers.org/en/papers/39487838