水素水の経口摂取：生物医学的効果・作用機序・臨床応用に関するレビュー
This review consolidates findings from basic science and clinical studies on the oral consumption of hydrogen-rich water (HRW). Documented biological activities include attenuation of oxidative stress, anti-inflammatory responses, modulation of glucose and lipid metabolism, preservation of mitochondrial function, and regulation of apoptotic pathways. Several mechanistic hypotheses have been proposed: direct neutralization of harmful free radicals, the Fe-porphyrin biosensor model, modulation of biological enzymes, lipoprotein-mediated regulation, and effects on the intestinal barrier. Clinically, HRW has been explored as an adjunct intervention, for disease prevention, and for quality-of-life enhancement. The authors conclude that larger-scale, well-designed clinical trials are necessary to substantiate these findings and expand practical applications.
H2 is proposed to act via direct scavenging of toxic free radicals, an Fe-porphyrin biosensor mechanism, modulation of biological enzymes, lipoprotein-mediated pathways, and effects on the intestinal barrier, collectively reducing oxidative stress and inflammation.
Hydrogen-rich water is a low-risk delivery route, but the achievable systemic hydrogen dose is bounded. For clinical applications, inhalation is the most efficient route; inhalation, however, carries explosion risk, and concentration matters (empirical LFL of 10% applies to inhalation environments; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).
See also:
https://h2-papers.org/en/papers/39810534