水素分子による血管性認知症マウスモデルでのT細胞分化調節と神経再生促進効果
Using a bilateral common carotid artery stenosis model of vascular dementia (VaD) in adult male C57BL/6 mice, this study examined the effects of hydrogen-rich water (HRW) administration across three groups: VaD, VaD with HRW, and sham controls. Behavioral testing revealed that anxiety-deficient behavior and memory impairment characteristic of VaD were ameliorated by HRW. Histological analysis demonstrated that pyknotic neuronal changes and elevated reactive oxygen species in the hippocampus were reduced following hydrogen administration. BCL2 downregulation observed in VaD mice was restored in the HRW group, accompanied by increased IL-4 expression. Flow cytometric data indicated that the VaD-associated expansion of regulatory T cells was normalized by HRW, suggesting restoration of immune homeostasis. Transcriptomic profiling further confirmed that neuroprotective and anti-inflammatory gene expression suppressed by VaD was recovered or augmented with hydrogen supplementation. These results collectively indicate that molecular hydrogen exerts neuroprotective and immunomodulatory effects in a VaD context.
Hydrogen-rich water reduces hippocampal ROS accumulation, restores BCL2 expression, elevates IL-4 levels, and normalizes regulatory T cell proportions, collectively contributing to neuroprotection and immune balance in vascular dementia.
Hydrogen-rich water is a low-risk delivery route, but the achievable systemic hydrogen dose is bounded. For clinical applications, inhalation is the most efficient route; inhalation, however, carries explosion risk, and concentration matters (empirical LFL of 10% applies to inhalation environments; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).
See also:
https://h2-papers.org/en/papers/39857445