酸化ストレスおよび疾患緩和における分子状水素の栄養学的応用：メカニズムと展望に関する包括的レビュー
Oxidative stress underlies the pathogenesis of numerous diseases, and molecular hydrogen (H₂) has attracted growing biomedical interest over the past two decades for its selective reactivity toward the most damaging reactive species, namely hydroxyl radicals and peroxynitrite. Beyond antioxidant activity, H₂ exhibits anti-inflammatory, anti-apoptotic, anti-allergic, and anti-cancer properties, while also modulating antioxidant enzyme gene expression, redox balance, pro-inflammatory cytokine levels, energy metabolism, and vascular endothelial function, as well as providing neuroprotection. Experimental and clinical evidence supports potential applications across cardiovascular, respiratory, metabolic, gastrointestinal, and neurological conditions, including obesity. Multiple delivery routes have been investigated, encompassing inhalation, hydrogen-rich water, hydrogen-rich saline, hydrogen-enriched eye drops, and hydrogen-rich bathing. This review systematically consolidates current mechanistic understanding and the latest research findings on H₂ applications across these disease categories.
H₂ selectively scavenges hydroxyl radicals and peroxynitrite, modulates antioxidant enzyme gene expression, maintains redox balance, suppresses pro-inflammatory cytokines, and stimulates energy metabolism, collectively producing cytoprotective effects across multiple organ systems.
This study combines multiple delivery routes. As a general principle, the most efficient route for routine hydrogen intake is inhalation. Inhalation carries explosion risk (empirical LFL of 10%; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).
See also:
https://h2-papers.org/en/papers/39911528