分子状水素の精密免疫調節への応用：送達システム・検出法・作用機序の包括的レビュー
This review systematically examines the immunomodulatory properties of molecular hydrogen (H₂), focusing on three areas that prior nanomaterial-oriented reviews have insufficiently addressed: mechanistic pathways, in vivo detection methods, and advanced delivery system classification. H₂ is reported to support immune homeostasis through antioxidant activity, suppression of pro-inflammatory mediators, and inhibition of apoptotic signaling. Two unresolved challenges are highlighted: the incomplete mechanistic understanding of H₂-mediated immune regulation and the absence of precise detection tools needed to establish dose-efficacy relationships in living systems. By consolidating recent advances in H₂ delivery platforms alongside updated detection strategies, the review aims to provide a framework for developing precision immunomodulation approaches that leverage the physicochemical properties of H₂.
H₂ is proposed to maintain immune homeostasis by selectively scavenging reactive oxygen species, downregulating pro-inflammatory cytokine production, and inhibiting apoptotic signaling cascades, collectively supporting a balanced immune response.
This study combines multiple delivery routes. As a general principle, the most efficient route for routine hydrogen intake is inhalation. Inhalation carries explosion risk (empirical LFL of 10%; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).
See also:
https://h2-papers.org/en/papers/40619605