全身性エリテマトーデスに伴う心膜炎・胸膜炎に対する分子状水素の免疫調節効果：症例報告
A 49-year-old Taiwanese woman with systemic lupus erythematosus (SLE) complicated by pericarditis, pleuritis, and multi-organ involvement experienced recurrent disease flares despite conventional immunomodulatory management. In October 2024, molecular hydrogen supplementation was added as an adjunct intervention. Subsequent immunophenotypic analysis demonstrated notable shifts in immune cell populations: a declining trend in Tr1 regulatory cells alongside increasing proportions of naive Treg cells, Fas-expressing B cell subsets, and transitional B cells. These findings suggest that molecular hydrogen may influence immune cell dynamics in autoimmune conditions. The authors note that broader clinical studies are needed to establish efficacy and safety profiles before definitive conclusions can be drawn.
Molecular hydrogen's antioxidant, anti-inflammatory, and antiapoptotic properties are proposed to underlie observed shifts in immune cell composition, including reduced Tr1 cells and increased naive Treg cells, Fas-expressing B cell subsets, and transitional B cells in an SLE patient.
The delivery route is not clearly identifiable from this paper. For hydrogen intake, inhalation is the most efficient route; inhalation, however, carries explosion risk (empirical LFL of 10%; high-concentration devices are not recommended).
See also:
https://h2-papers.org/en/papers/40877145