アレルギー性鼻炎に対する各種鼻腔洗浄法の有効性：システマティックレビューおよびネットワークメタ解析
A systematic review and network meta-analysis was conducted to evaluate the comparative efficacy of various nasal irrigation agents in patients with allergic rhinitis (AR). Seven databases were searched through March 2025, yielding 23 eligible studies encompassing 3,584 participants. Primary outcomes were Total Nasal Symptom Score (TNSS) and secondary outcomes were Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ) scores. For nasal symptom relief, resveratrol ranked highest (MD: −7.7, 95% CrI: −14.0 to −1.1; SUCRA = 92.08%), followed by budesonide (MD: −5.6; SUCRA = 83.39%). For quality-of-life improvement, cinnamon bark ranked first (MD: −1.3; SUCRA = 95.78%), with hydrogen-rich water ranking second (MD: −1.2, 95% CrI: −2.4 to 0.10; SUCRA = 82.58%), though its credibility interval marginally included zero. Fluticasone also demonstrated significant improvement. The findings suggest that botanical agents, including resveratrol and cinnamon, as well as hydrogen-rich water, may offer clinically relevant benefits as nasal irrigation solutions for AR.
The specific mechanism of hydrogen-rich water in nasal irrigation was not detailed in this meta-analysis; antioxidant and anti-inflammatory properties are presumed to underlie any observed benefit.
Topical applications have localized-effect reports, but systemic hydrogen intake is most efficient via inhalation. Inhalation carries explosion risk (empirical LFL of 10%; high-concentration devices are not recommended).
See also:
https://h2-papers.org/en/papers/41293244