Safety of hydrogen inhalers

Aggregated literature, accident records, and regulatory background on the safety of hydrogen inhalation. Safe concentration handling matters: the classical 4% LFL is a closed-system value; the empirical inhalation-environment ceiling is approximately 10%. See the inhalation concentration explainer for the rationale.

Related papers (7)

Sixty-minute inhalation of molecular hydrogen decreases blood oxygen saturation but does not alter autonomic cardiac regulation at rest in healthy females: a randomized, double-blind, placebo-controlled crossover study.
Can J Physiol Pharmacol 2026 — human randomized controlled trial — inhalation — mixed
Respiratory-physiology modeling of therapeutic hydrogen inhalation: defining the fraction of inspired hydrogen (FiH) and flow-rate requirements.
Respir Res 2026 — other — inhalation — not assessed
Performance of Unmodified Mechanical Ventilators With 2% Hydrogen Gas Mixtures.
Respir Care 2025 — other — inhalation — not assessed
Hydrogen inhalation: in vivo rat genotoxicity tests.
Mutat Res Genet Toxicol Environ Mutagen 2024 — animal study — inhalation — null
Hinhalation therapy in patients with moderate COVID-19 (HCOVID): a prospective ascending-dose phase I clinical trial.
Antimicrob Agents Chemother 2024 — human case report — inhalation — positive
Low-Flow Nasal Cannula Hydrogen Therapy.
J Clin Med Res 2020 — animal study — inhalation — positive
A basic study on molecular hydrogen (H2) inhalation in acute cerebral ischemia patients for safety check with physiological parameters and measurement of blood H2 level.
Med Gas Res 2012 — human case report — inhalation — positive

Related safety notes

Cite as: H2 Papers — https://h2-papers.org/en/topics/inhalers/safety