H₂
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aging / frailty
37 papers
Delivery-method distribution
hydrogen-rich water: 15
mixed routes: 7
in vitro: 5
inhalation: 4
topical application: 2
not specified: 2
hydrogen bath: 1
animal model: 1
Effects of hydrogen-rich water bath on visceral fat and skin blotch, with boiling-resistant hydrogen bubbles.
2019 ・ Med Gas Res ・ PMID 31249254
hydrogen bath
mixed
human case report
Administration of hydrogen-rich water prevents vascular aging of the aorta in LDL receptor-deficient mice.
2018 ・ Sci Rep ・ PMID 30429524
hydrogen-rich water
positive
animal study
Molecular hydrogen affects body composition, metabolic profiles, and mitochondrial function in middle-aged overweight women.
2018 ・ Ir J Med Sci ・ PMID 28560519
hydrogen-rich water
mixed
human randomized controlled trial
Hydrogen-rich water for improvements of mood, anxiety, and autonomic nerve function in daily life.
2017 ・ Med Gas Res ・ PMID 29497485
hydrogen-rich water
positive
human randomized controlled trial
Hydrogen gas protects IP3Rs by reducing disulfide bridges in human keratinocytes under oxidative stress.
2017 ・ Sci Rep ・ PMID 28620198
in vitro
positive
in vitro study
Hydrogen Treatment Protects against Cell Death and Senescence Induced by Oxidative Damage.
2017 ・ J Microbiol Biotechnol ・ PMID 27780950
in vitro
positive
in vitro study
Molecular hydrogen stimulates the gene expression of transcriptional coactivator PGC-1α to enhance fatty acid metabolism.
2016 ・ NPJ Aging Mech Dis ・ PMID 28721265
hydrogen-rich water
positive
animal study
Molecular Hydrogen Alleviates Cellular Senescence in Endothelial Cells.
2016 ・ Circ J ・ PMID 27477846
in vitro
positive
in vitro study
Prediction of binding modes between protein L-isoaspartyl (D-aspartyl) O-methyltransferase and peptide substrates including isomerized aspartic acid residues using in silico analytic methods for the substrate screening.
2015 ・ J Pharm Biomed Anal ・ PMID 25758062
in vitro
not assessed
in vitro study
Effects of hydrogen-rich water on aging periodontal tissues in rats.
2014 ・ Sci Rep ・ PMID 24985521
hydrogen-rich water
mixed
animal study
Mechanism of the lifespan extension of Caenorhabditis elegans by electrolyzed reduced water--participation of Pt nanoparticles.
2011 ・ Biosci Biotechnol Biochem ・ PMID 21737933
hydrogen-rich water
mixed
animal study
Recent progress toward hydrogen medicine: potential of molecular hydrogen for preventive and therapeutic applications.
2011 ・ Curr Pharm Des ・ PMID 21736547
mixed routes
not assessed
review
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