H₂
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apoptosis regulation
280 papers
Delivery-method distribution
mixed routes: 61
hydrogen-rich water: 61
inhalation: 53
in vitro: 47
injection / infusion: 29
not specified: 22
topical application: 5
hydrogen bath: 1
animal model: 1
Inhaled Hor CODo Not Augment the Neuroprotective Effect of Therapeutic Hypothermia in a Severe Neonatal Hypoxic-Ischemic Encephalopathy Piglet Model.
2020 ・ Int J Mol Sci ・ PMID 32948011
inhalation
null
animal study
Prospects of molecular hydrogen in perioperative neuroprotection from basic research to clinical application.
2020 ・ Curr Opin Anaesthesiol ・ PMID 32826628
mixed routes
not assessed
review
Hydrogen inhalation inhibits microglia activation and neuroinflammation in a rat model of traumatic brain injury.
2020 ・ Brain Res ・ PMID 32814064
inhalation
positive
animal study
Hydrogen gas inhalation improves delayed brain injury by alleviating early brain injury after experimental subarachnoid hemorrhage.
2020 ・ Sci Rep ・ PMID 32704088
inhalation
positive
animal study
Hydrogen-rich water reduces inflammatory responses and prevents apoptosis of peripheral blood cells in healthy adults: a randomized, double-blind, controlled trial.
2020 ・ Sci Rep ・ PMID 32699287
hydrogen-rich water
mixed
human randomized controlled trial
A study on the protective effect of molecular hydrogen on osteoradionecrosis of the jaw in rats.
2020 ・ Int J Oral Maxillofac Surg ・ PMID 32451233
mixed routes
positive
animal study
Chronic molecular hydrogen inhalation mitigates short and long-term memory loss in polymicrobial sepsis.
2020 ・ Brain Res ・ PMID 32348775
inhalation
positive
animal study
Oral Administration of Si-Based Agent Attenuates Oxidative Stress and Ischemia-Reperfusion Injury in a Rat Model: A Novel Hydrogen Administration Method.
2020 ・ Front Med (Lausanne) ・ PMID 32266279
hydrogen-rich water
positive
animal study
Molecular Hydrogen Protects Human Melanocytes from Oxidative Stress by Activating Nrf2 Signaling.
2020 ・ J Invest Dermatol ・ PMID 32234461
in vitro
positive
in vitro study
Hydrogen-rich water alleviates cyclosporine A-induced nephrotoxicity via the Keap1/Nrf2 signaling pathway.
2020 ・ J Biochem Mol Toxicol ・ PMID 32040235
hydrogen-rich water
positive
animal study
Protective Effects of Hydrogen-Rich Water Against Cartilage Damage in a Rat Model of Osteoarthritis by Inhibiting Oxidative Stress, Matrix Catabolism, and Apoptosis.
2020 ・ Med Sci Monit ・ PMID 31927559
injection / infusion
positive
animal study
Hydrogen inhibits endometrial cancer growth via a ROS/NLRP3/caspase-1/GSDMD-mediated pyroptotic pathway.
2020 ・ BMC Cancer ・ PMID 31924176
hydrogen-rich water
positive
animal study
Protective effects of hydrogen‑rich saline against experimental diabetic peripheral neuropathy via activation of the mitochondrial ATP‑sensitive potassium channel channels in rats.
2020 ・ Mol Med Rep ・ PMID 31746358
injection / infusion
positive
animal study
Effects of Hydrogen-rich Water on the PI3K/AKT Signaling Pathway in Rats with Myocardial Ischemia-reperfusion Injury.
2020 ・ Curr Mol Med ・ PMID 31702499
hydrogen-rich water
positive
animal study
Inhalation of molecular hydrogen prevents ischemia-reperfusion liver damage during major liver resection.
2019 ・ Ann Transl Med ・ PMID 32042790
inhalation
positive
animal study
Molecular hydrogen: current knowledge on mechanism in alleviating free radical damage and diseases.
2019 ・ Acta Biochim Biophys Sin (Shanghai) ・ PMID 31738389
not specified
not assessed
review
Effect of Htreatment in a mouse model of rheumatoid arthritis-associated interstitial lung disease.
2019 ・ J Cell Mol Med ・ PMID 31424157
hydrogen-rich water
positive
animal study
Effects of Molecular Hydrogen on Methamphetamine-Induced Neurotoxicity and Spatial Memory Impairment.
2019 ・ Front Pharmacol ・ PMID 31396089
hydrogen-rich water
positive
animal study
[Protective effect of hydrogen-rich water on oxidative stress cell model and the impact of the phosphatidylinositol 3 kinase/protein kinase B pathway].
2019 ・ Zhonghua Wei Zhong Bing Ji Jiu Yi Xue ・ PMID 31315738
in vitro
positive
in vitro study
Molecular hydrogen suppresses free-radical-induced cell death by mitigating fatty acid peroxidation and mitochondrial dysfunction.
2019 ・ Can J Physiol Pharmacol ・ PMID 31295412
in vitro
positive
in vitro study
Recent Advances in Studies of Molecular Hydrogen against Sepsis.
2019 ・ Int J Biol Sci ・ PMID 31223285
not specified
not assessed
review
A New Approach for the Prevention and Treatment of Cardiovascular Disorders. Molecular Hydrogen Significantly Reduces the Effects of Oxidative Stress.
2019 ・ Molecules ・ PMID 31159153
mixed routes
not assessed
review
Molecular hydrogen suppresses glioblastoma growth via inducing the glioma stem-like cell differentiation.
2019 ・ Stem Cell Res Ther ・ PMID 31113492
inhalation
positive
animal study
Acid-Responsive H-Releasing 2D MgBNanosheet for Therapeutic Synergy and Side Effect Attenuation of Gastric Cancer Chemotherapy.
2019 ・ Adv Healthc Mater ・ PMID 30968583
mixed routes
positive
animal study
Attenuation of Cardiac Ischaemia-reperfusion Injury by Treatment with Hydrogen-rich Water.
2019 ・ Curr Mol Med ・ PMID 30907314
hydrogen-rich water
positive
animal study
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