H₂
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apoptosis regulation
280 papers
Delivery-method distribution
mixed routes: 61
hydrogen-rich water: 61
inhalation: 53
in vitro: 47
injection / infusion: 29
not specified: 22
topical application: 5
hydrogen bath: 1
animal model: 1
Molecular Hydrogen Attenuated N-methyl-N-Nitrosourea Induced Corneal Endothelial Injury by Upregulating Anti-Apoptotic Pathway.
2021 ・ Invest Ophthalmol Vis Sci ・ PMID 34196654
mixed routes
positive
animal study
Electrolyzed Hydrogen Water Protects against Ethanol-Induced Cytotoxicity by Regulating Aldehyde Metabolism-Associated Enzymes in the Hepatic Cell Line HepG2.
2021 ・ Antioxidants (Basel) ・ PMID 34069398
in vitro
positive
in vitro study
Combined treatment with dissolved hydrogen molecule and platinum nanocolloid exerts carcinostatic/carcinocidal effects by increasing hydrogen peroxide generation and cell death in the human gastric cancer cell line NUGC-4.
2021 ・ Free Radic Res ・ PMID 33929281
in vitro
positive
in vitro study
Molecular Hydrogen as a Potential Clinically Applicable Radioprotective Agent.
2021 ・ Int J Mol Sci ・ PMID 33925430
mixed routes
not assessed
review
Hydrogen-rich water alleviates programmed cell death induced by GA in wheat aleurone layers by modulation of reactive oxygen species metabolism.
2021 ・ Plant Physiol Biochem ・ PMID 33901885
in vitro
positive
in vitro study
Protective effects of molecular hydrogen on lung injury from lung transplantation.
2021 ・ Exp Biol Med (Maywood) ・ PMID 33899545
mixed routes
not assessed
review
Molecular hydrogen alleviates asthma through inhibiting IL-33/ILC2 axis.
2021 ・ Inflamm Res ・ PMID 33852061
inhalation
positive
animal study
Potential Therapeutic Applications of Hydrogen in Chronic Inflammatory Diseases: Possible Inhibiting Role on Mitochondrial Stress.
2021 ・ Int J Mol Sci ・ PMID 33806292
not specified
not assessed
review
Chemical and Biochemical Aspects of Molecular Hydrogen in Treating Kawasaki Disease and COVID-19.
2021 ・ Chem Res Toxicol ・ PMID 33719401
inhalation
not assessed
review
Antitumor Activity of Protons and Molecular Hydrogen: Underlying Mechanisms.
2021 ・ Cancers (Basel) ・ PMID 33672714
mixed routes
not assessed
review
Protective Effects of Hydrogen against Irradiation.
2021 ・ Curr Pharm Des ・ PMID 33463456
mixed routes
not assessed
review
Hydrogen-rich water protects against liver injury in nonalcoholic steatohepatitis through HO-1 enhancement via IL-10 and Sirt 1 signaling.
2021 ・ Am J Physiol Gastrointest Liver Physiol ・ PMID 33439102
hydrogen-rich water
positive
animal study
Molecular hydrogen downregulates acute exhaustive exercise-induced skeletal muscle damage.
2021 ・ Can J Physiol Pharmacol ・ PMID 33356867
inhalation
positive
animal study
Hydrogen-rich water attenuates the radiotoxicity induced by tritium exposure in vitro and in vivo.
2021 ・ J Radiat Res ・ PMID 33231266
mixed routes
positive
animal study
Hydrogen-induced Neuroprotection in Neonatal Hypoxic-ischemic Encephalopathy.
2021 ・ Curr Pharm Des ・ PMID 33185158
mixed routes
positive
review
The Potential of Hydrogen for Improving Mental Disorders.
2021 ・ Curr Pharm Des ・ PMID 33185151
not specified
not assessed
review
Recent advances in studies of molecular hydrogen in the treatment of pancreatitis.
2021 ・ Life Sci ・ PMID 33148420
not specified
not assessed
review
Neuroprotective Effects of Molecular Hydrogen: A Critical Review.
2021 ・ Neurosci Bull ・ PMID 33078374
mixed routes
not assessed
review
Oxidative Stress and Pathways of Molecular Hydrogen Effects in Medicine.
2021 ・ Curr Pharm Des ・ PMID 32954996
not specified
not assessed
review
Perspective of Molecular Hydrogen in the Treatment of Sepsis.
2021 ・ Curr Pharm Des ・ PMID 32912119
mixed routes
not assessed
review
Protective Effects of a Hydrogen-Rich Preservation Solution in a Canine Lung Transplantation Model.
2021 ・ Ann Thorac Surg ・ PMID 32649946
injection / infusion
positive
animal study
Hydrogen Gas Alleviates Sepsis-Induced Brain Injury by Improving Mitochondrial Biogenesis Through the Activation of PGC-α in Mice.
2021 ・ Shock ・ PMID 32590694
inhalation
positive
animal study
Inhaled Gases as Therapies for Post-Cardiac Arrest Syndrome: A Narrative Review of Recent Developments.
2020 ・ Front Med (Lausanne) ・ PMID 33585501
inhalation
not assessed
review
Molecular and Cellular Mechanisms Associated with Effects of Molecular Hydrogen in Cardiovascular and Central Nervous Systems.
2020 ・ Antioxidants (Basel) ・ PMID 33333951
mixed routes
not assessed
review
Hydrogen: A Potential New Adjuvant Therapy for COVID-19 Patients.
2020 ・ Front Pharmacol ・ PMID 33178011
inhalation
not assessed
review
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