H₂
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cognitive decline
111 papers
Delivery-method distribution
inhalation: 42
hydrogen-rich water: 35
mixed routes: 14
not specified: 13
injection / infusion: 2
in vitro: 2
animal model: 2
topical application: 1
Emerging Trends and Hot Spots in Sepsis-Associated Encephalopathy Research From 2001 to 2021: A Bibliometric Analysis.
2022 ・ Front Med (Lausanne) ・ PMID 35295600
not specified
not assessed
other
Hydrogen-rich water ameliorates neuropathological impairments in a mouse model of Alzheimer's disease through reducing neuroinflammation and modulating intestinal microbiota.
2022 ・ Neural Regen Res ・ PMID 34269217
hydrogen-rich water
positive
animal study
The Role of Hyperthermia in Methamphetamine-Induced Depression-Like Behaviors: Protective Effects of Coral Calcium Hydride.
2021 ・ Front Mol Neurosci ・ PMID 35058751
animal model
positive
animal study
Therapeutic Effects of Hydrogen Gas Inhalation on Trimethyltin-Induced Neurotoxicity and Cognitive Impairment in the C57BL/6 Mice Model.
2021 ・ Int J Mol Sci ・ PMID 34948107
inhalation
positive
animal study
Hydrogen-Rich Water Improves Cognitive Ability and Induces Antioxidative, Antiapoptotic, and Anti-Inflammatory Effects in an Acute Ischemia-Reperfusion Injury Mouse Model.
2021 ・ Biomed Res Int ・ PMID 34746315
hydrogen-rich water
positive
animal study
An H2-infused, nitric oxide-producing functional beverage as a neuroprotective agent for TBIs and concussions.
2021 ・ J Integr Neurosci ・ PMID 34645100
hydrogen-rich water
not assessed
review
Amyloid β structural polymorphism, associated toxicity and therapeutic strategies.
2021 ・ Cell Mol Life Sci ・ PMID 34643743
not specified
not assessed
review
The effects of 6-month hydrogen-rich water intake on molecular and phenotypic biomarkers of aging in older adults aged 70 years and over: A randomized controlled pilot trial.
2021 ・ Exp Gerontol ・ PMID 34601077
hydrogen-rich water
mixed
human randomized controlled trial
Hydrogen gas alleviates sepsis-induced neuroinflammation and cognitive impairment through regulation of DNMT1 and DNMT3a-mediated BDNF promoter IV methylation in mice.
2021 ・ Int Immunopharmacol ・ PMID 33773206
inhalation
positive
animal study
Inhaled gases as novel neuroprotective therapies in the postcardiac arrest period.
2021 ・ Curr Opin Crit Care ・ PMID 33769417
inhalation
not assessed
review
Hydrogen as a Potential Therapeutic in Obesity: Targeting the Brain.
2021 ・ Trends Endocrinol Metab ・ PMID 33485760
inhalation
not assessed
review
The Potential of Hydrogen for Improving Mental Disorders.
2021 ・ Curr Pharm Des ・ PMID 33185151
not specified
not assessed
review
Neuroprotective Effects of Molecular Hydrogen: A Critical Review.
2021 ・ Neurosci Bull ・ PMID 33078374
mixed routes
not assessed
review
Neuroprotective and Preventative Effects of Molecular Hydrogen.
2021 ・ Curr Pharm Des ・ PMID 33076798
hydrogen-rich water
not assessed
review
Hydrogen Gas Alleviates Sepsis-Induced Brain Injury by Improving Mitochondrial Biogenesis Through the Activation of PGC-α in Mice.
2021 ・ Shock ・ PMID 32590694
inhalation
positive
animal study
Hydrogen and therapeutic gases for neonatal hypoxic-ischemic encephalopathy: potential neuroprotective adjuncts in translational research.
2021 ・ Pediatr Res ・ PMID 32505123
inhalation
not assessed
review
Molecular hydrogen alleviates brain injury and cognitive impairment in a chronic sequelae model of murine polymicrobial sepsis.
2020 ・ Exp Brain Res ・ PMID 33052428
inhalation
positive
animal study
Prospects of molecular hydrogen in perioperative neuroprotection from basic research to clinical application.
2020 ・ Curr Opin Anaesthesiol ・ PMID 32826628
mixed routes
not assessed
review
Hydrogen gas alleviates blood-brain barrier impairment and cognitive dysfunction of septic mice in an Nrf2-dependent pathway.
2020 ・ Int Immunopharmacol ・ PMID 32447221
inhalation
positive
animal study
Chronic molecular hydrogen inhalation mitigates short and long-term memory loss in polymicrobial sepsis.
2020 ・ Brain Res ・ PMID 32348775
inhalation
positive
animal study
Molecular hydrogen attenuates sepsis-induced neuroinflammation through regulation of microglia polarization through an mTOR-autophagy-dependent pathway.
2020 ・ Int Immunopharmacol ・ PMID 32058932
inhalation
positive
animal study
Inhaled molecular hydrogen attenuates intense acute exercise-induced hippocampal inflammation in sedentary rats.
2020 ・ Neurosci Lett ・ PMID 31715290
inhalation
positive
animal study
Effect of Hydrogen-Rich Water on Radiation-Induced Cognitive Dysfunction in Rats.
2020 ・ Radiat Res ・ PMID 31634054
hydrogen-rich water
positive
animal study
Case Report: Buccal administration of hydrogen-producing blend after a mild traumatic brain injury in a professional athlete.
2019 ・ F1000Res ・ PMID 32595937
topical application
positive
human case report
Effects of Molecular Hydrogen on Methamphetamine-Induced Neurotoxicity and Spatial Memory Impairment.
2019 ・ Front Pharmacol ・ PMID 31396089
hydrogen-rich water
positive
animal study
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