プロサッカー選手における軽度外傷性脳損傷後の水素産生製剤の口腔粘膜投与：症例報告
A professional soccer player who sustained a sport-related mild traumatic brain injury (TBI) received a hydrogen-producing dissolving tablet via buccal (oral transmucosal) administration beginning approximately 15 minutes post-injury, with doses repeated every 2 hours over a 24-hour period. Assessment using the Sport Concussion Assessment Tool 2 (SCAT2) showed improvement from a baseline score of 68 (indicating severe disruption) to 84 (mild disruption) at the 24-hour follow-up. No adverse effects were reported throughout the intervention period. The findings suggest that molecular hydrogen, known for its ability to readily penetrate brain tissue, may offer neuroprotective benefits as an early-stage intervention following mild TBI, representing a potentially useful option where conventional approaches are limited.
Molecular hydrogen readily crosses into brain tissue and is thought to exert neuroprotective effects, potentially reducing neurological dysfunction following traumatic injury through antioxidant and anti-inflammatory mechanisms.
Topical applications have localized-effect reports, but systemic hydrogen intake is most efficient via inhalation. Inhalation carries explosion risk (empirical LFL of 10%; high-concentration devices are not recommended).
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https://h2-papers.org/en/papers/32595937