H₂
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oxidative stress
899 papers
Delivery-method distribution
hydrogen-rich water: 313
inhalation: 153
mixed routes: 150
in vitro: 103
injection / infusion: 72
not specified: 66
topical application: 19
animal model: 15
hydrogen bath: 8
Transcriptome-Based Evaluation of Hydrogen Gas Effects for Preventing UVA-Induced Photoaging Using an Artificial Skin Model.
2026 ・ Geriatr Gerontol Int ・ PMID 41749059
in vitro
positive
in vitro study
The protective effects of molecular hydrogen in sepsis-associated encephalopathy: current status.
2026 ・ Eur J Pharmacol ・ PMID 41747800
mixed routes
not assessed
review
Electrolyzed Hydrogen Water Improves Chemosensitivity to Anticancer Drugs by Potently Suppressing Autophagy.
2026 ・ J Cell Mol Med ・ PMID 41702867
in vitro
positive
in vitro study
Acoustic hydrogen delivery to treat PANoptosis induced by myocardial ischemia/reperfusion injury in rats.
2026 ・ Biomater Adv ・ PMID 41671925
injection / infusion
positive
animal study
Magnesium silicate nanosheets enable sustained hydrogen release to attenuate secondary brain injury following intracerebral hemorrhage.
2026 ・ J Transl Med ・ PMID 41654898
mixed routes
positive
animal study
Hydrogen-rich water improves endurance by reducing skeletal muscle oxidative stress and inflammatory responses.
2026 ・ Front Nutr ・ PMID 41641160
hydrogen-rich water
positive
animal study
Molecular hydrogen therapy in musculoskeletal conditions: An evidence-based review and critical analysis.
2026 ・ World J Orthop ・ PMID 41608485
mixed routes
positive
review
Molecular Hydrogen Attenuates Chronic Inflammation and Delays the Onset of Ultraviolet B-Induced Skin Carcinogenesis in Mice.
2026 ・ Int J Mol Sci ・ PMID 41596287
mixed routes
positive
animal study
Hydrogen inhalation is associated with a transient rightward shift in prefrontal oxyhemoglobin asymmetry and autonomic modulation.
2026 ・ Sci Rep ・ PMID 41582106
inhalation
positive
human observational study
Exploratory Evaluation of Hydrogen-Rich Water Therapy for Keloid Management: A Double-Blinded Randomized Pilot Trial.
2026 ・ Aesthetic Plast Surg ・ PMID 41545661
hydrogen-rich water
positive
human randomized controlled trial
Hydrogen ameliorates psoriasis-like skin inflammation via inhibiting the cGAS-STING pathway.
2026 ・ Clin Exp Immunol ・ PMID 41533764
mixed routes
positive
animal study
Revisiting molecular hydrogen signaling in mitochondria: Is the Rieske protein the entry point or a downstream sentinel?
2026 ・ Redox Biol ・ PMID 41496215
not specified
not assessed
review
Medical Gases as Emerging Regulators of Paediatric Endocrine and Neurodevelopmental Pathways: A Mini-Review.
2026 ・ Acta Paediatr ・ PMID 41482991
not specified
not assessed
review
Rhupus Syndrome With Multiple Drug Intolerances Managed by Reduced-dose Rituximab and Adjunctive Molecular Hydrogen Therapy: A Case Report.
2026 ・ In Vivo ・ PMID 41482402
hydrogen-rich water
positive
human case report
Adjuvant Molecular Hydrogen Therapy in SLE-associated Pulmonary Arterial Hypertension: A Case Report on Immunomodulatory Effects on Regulatory and Effector Lymphocytes.
2026 ・ In Vivo ・ PMID 41482388
hydrogen-rich water
positive
human case report
Emerging Clinical Applications for Molecular Hydrogen.
2026 ・ Respir Care ・ PMID 41449652
inhalation
not assessed
review
Osteoimmunometabolic modulation via hydrogen-self-supplying magnesium-reinforced collagen membrane for enhanced guided bone regeneration.
2026 ・ Biomaterials ・ PMID 41435455
in vitro
positive
animal study
Influence of hydrogen-rich water on spermatogenesis and sperm parameters in experimentally induced hypothyroidism and subclinical hypothyroidism models.
2026 ・ Reprod Toxicol ・ PMID 41421768
hydrogen-rich water
positive
animal study
Sixty-minute inhalation of molecular hydrogen decreases blood oxygen saturation but does not alter autonomic cardiac regulation at rest in healthy females: a randomized, double-blind, placebo-controlled crossover study.
2026 ・ Can J Physiol Pharmacol ・ PMID 41401441
inhalation
mixed
human randomized controlled trial
Hydrogen gas promotes neuroprotection and upregulates ATF5 expression in neonatal hypoxic-ischemic brain injury.
2026 ・ Exp Neurol ・ PMID 41386344
inhalation
positive
animal study
Postharvest preservation of chestnuts: Combined application of hydrogen-rich water and a carboxymethyl chitosan/sodium alginate composite coating.
2026 ・ Int J Biol Macromol ・ PMID 41314584
hydrogen-rich water
positive
other
Therapeutic potential of magnesium diboride nanosheets in PAH-associated right heart failure: Integrated multi-omics analysis reveals ferroptosis suppression via LC3/ATG5/NCOA4/FTH1 pathway.
2026 ・ Free Radic Biol Med ・ PMID 41308938
in vitro
positive
animal study
Gas Therapies for Neuro-Protection.
2026 ・ Crit Care Clin ・ PMID 41260719
inhalation
not assessed
review
Advances in hydrogen delivery strategies for therapeutic applications.
2026 ・ Adv Drug Deliv Rev ・ PMID 41232804
mixed routes
not assessed
review
Hydrogen intervention attenuates chronic hypoxia-induced bone degeneration and multi-organ damage via modulation of the gut microbiota.
2026 ・ Bone ・ PMID 41224067
hydrogen-rich water
positive
animal study
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