水素水摂取がケロイド患者の炎症および症状に与える影響：二重盲検無作為化パイロット試験
A double-blind randomized pilot trial enrolled 21 keloid patients undergoing two-stage surgical procedures, allocating them to either a hydrogen-rich water (HRW) group or a control group receiving hydrogen-free water. Following the intervention period, the HRW group demonstrated significantly reduced frequency of pain and pruritus. Vancouver Scar Scale total scores and pigmentation subdomain scores also declined significantly. Molecular analyses via western blotting, qPCR, and ELISA revealed decreased expression of the pruritus-associated cytokine TRPV1 and the keloid-associated factor HIF-1α, alongside elevated anti-inflammatory IL-10 and reduced pro-inflammatory mediators VEGF and TGF-β. These early clinical signals suggest that hydrogen-rich water consumption may modulate inflammatory pathways relevant to keloid pathophysiology and symptom burden, warranting larger confirmatory trials.
Hydrogen-rich water intake was associated with downregulation of the pruritus-related receptor TRPV1 and keloid-associated HIF-1α, upregulation of anti-inflammatory IL-10, and reduction of pro-inflammatory VEGF and TGF-β, collectively suggesting suppression of inflammatory and itch-related signaling in keloid tissue.
Hydrogen-rich water is a low-risk delivery route, but the achievable systemic hydrogen dose is bounded. For clinical applications, inhalation is the most efficient route; inhalation, however, carries explosion risk, and concentration matters (empirical LFL of 10% applies to inhalation environments; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).
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https://h2-papers.org/en/papers/41545661