二次元MgSiナノシートによる持続的水素発生を利用した深度熱傷皮膚の修復・再生促進
A two-dimensional magnesium silicide (MgSi) nanosheet (MSN) was developed as a highly biocompatible, long-acting hydrogen-releasing nanomaterial. When embedded within a chitosan/hyaluronic acid hydrogel matrix (MSN@CS/HA), the resulting dressing continuously produced hydrogen molecules for approximately one week under physiological conditions. In a deep burn wound model, this sustained local hydrogen supply accelerated healing of deep second- and third-degree burns without scar formation or detectable toxicity. Mechanistic investigations revealed that prolonged hydrogen exposure promoted M2 macrophage polarization through upregulation of CCL2 (chemokine C-C motif ligand 2), thereby enhancing angiogenesis and reducing fibrosis. Concurrently, local scavenging of excess reactive oxygen species directly and indirectly improved the proliferation and migration of skin cells. These findings establish a framework for synthesizing MSene-class nanomaterials and expanding their application to pro-angiogenic contexts beyond wound repair.
Sustained H2 release upregulates CCL2 expression, driving M2 macrophage polarization to promote angiogenesis and suppress fibrosis, while local scavenging of excess reactive oxygen species enhances skin cell proliferation and migration.
Topical applications have localized-effect reports, but systemic hydrogen intake is most efficient via inhalation. Inhalation carries explosion risk (empirical LFL of 10%; high-concentration devices are not recommended).
See also:
https://h2-papers.org/en/papers/36546774