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Evidence base for hydrogen-rich water
Research on hydrogen-rich water (oral) organized by disease and effect. HRW is a low-risk delivery route, but the achievable systemic dose is bounded; for clinical applications inhalation is the most efficient route (→ safety notes).
Related papers (100)
- Mechanism by which hydrogen-rich water mitigates exercise-induced fatigue: activation of the immunoresponsive gene 1-itaconate/nuclear factor erythroid 2-related factor 2/heme oxygenase-1 pathway.
Med Gas Res 2026 — animal study — hydrogen-rich water — positive - Hydrogen-rich water alleviates neuropathic pain through the modulation of bile acid/Takeda G-protein-coupled receptor 5-mediated autophagy.
Pain 2026 — animal study — hydrogen-rich water — positive - Molecular hydrogen mitigates acetaminophen-induced liver injury and enhances the effects of N-acetylcysteine in diabetic mice.
J Nutr Biochem 2026 — animal study — hydrogen-rich water — positive - Hydrogen intervention attenuates chronic hypoxia-induced bone degeneration and multi-organ damage via modulation of the gut microbiota.
Bone 2026 — animal study — hydrogen-rich water — positive - Postharvest preservation of chestnuts: Combined application of hydrogen-rich water and a carboxymethyl chitosan/sodium alginate composite coating.
Int J Biol Macromol 2026 — other — hydrogen-rich water — positive - Influence of hydrogen-rich water on spermatogenesis and sperm parameters in experimentally induced hypothyroidism and subclinical hypothyroidism models.
Reprod Toxicol 2026 — animal study — hydrogen-rich water — positive - Adjuvant Molecular Hydrogen Therapy in SLE-associated Pulmonary Arterial Hypertension: A Case Report on Immunomodulatory Effects on Regulatory and Effector Lymphocytes.
In Vivo 2026 — human case report — hydrogen-rich water — positive - Rhupus Syndrome With Multiple Drug Intolerances Managed by Reduced-dose Rituximab and Adjunctive Molecular Hydrogen Therapy: A Case Report.
In Vivo 2026 — human case report — hydrogen-rich water — positive - Exploratory Evaluation of Hydrogen-Rich Water Therapy for Keloid Management: A Double-Blinded Randomized Pilot Trial.
Aesthetic Plast Surg 2026 — human randomized controlled trial — hydrogen-rich water — positive - Hydrogen-rich water improves endurance by reducing skeletal muscle oxidative stress and inflammatory responses.
Front Nutr 2026 — animal study — hydrogen-rich water — positive - Long-Term Consumption of Hydrogen-Rich Water Mitigates Oxidative Stress, Hepatic Inflammation, and Apoptosis in Rats with LPS-Induced Chronic Liver Injury.
Antioxidants (Basel) 2026 — animal study — hydrogen-rich water — positive - Adjunctive Molecular Hydrogen Therapy Modulates T Cell Markers and Reduces Anti-Ro Antibody in Refractory Oral Ulcers of Behçet's Disease and Sjögren's Syndrome: A Case Report.
In Vivo 2026 — human case report — hydrogen-rich water — positive - Enhanced phytoremediation of Cd-As co-contaminated farmland using hydrogen-rich water: Mechanisms and efficiency evaluation in Solanum nigrum L․.
J Environ Sci (China) 2026 — other — hydrogen-rich water — positive - The effect of hydrogen-rich water interventions on lipid profiles in adults with overweight or obesity and associated metabolic disorders: a systematic review and meta-analysis of randomized controlled trials.
Diabetol Metab Syndr 2026 — meta-analysis — hydrogen-rich water — not assessed - Silicon-based agent mitigates fatty liver formation in a CDAHFD60-induced MASH mouse model by enhancing hepatic function.
Biochem Biophys Rep 2026 — animal study — hydrogen-rich water — positive - Molecular hydrogen as a treatment for ME/CFS: a mini-review of clinical evidence and mechanistic rationale.
Front Med (Lausanne) 2026 — review — hydrogen-rich water — positive - Molecular Hydrogen Reverses Nociplastic Pain and Depressive-like Behaviors via Region- and Sex-Dependent Central Mechanisms.
Int J Mol Sci 2026 — animal study — hydrogen-rich water — positive - Hydrogen-Rich Water as a Performance-Enhancing Aid in National-Level Finswimmers: A Randomized, Double-Blind, Placebo-Controlled Crossover Study.
Int J Sports Physiol Perform 2026 — human randomized controlled trial — hydrogen-rich water — mixed - Adjunctive Molecular Hydrogen Capsule Therapy in Empyema Complicated by Chronic Inflammatory Demyelinating Polyneuropathy: A Case Report.
In Vivo 2026 — human case report — hydrogen-rich water — positive - Consumption of hydrogen-rich water ameliorates atherosclerosis by modulating gut microbiota and enhancing short-chain fatty acid levels.
Life Sci 2026 — animal study — hydrogen-rich water — positive - Protective effects of hydrogen-rich water against acute lead-induced hepatic, renal, and testicular toxicity in rats.
Naunyn Schmiedebergs Arch Pharmacol 2026 — animal study — hydrogen-rich water — positive - Molecular hydrogen inhibits neuroinflammation and ameliorates depressive-like behaviors and short-term cognitive impairment in senescence-accelerated mouse prone 8 mice.
Behav Brain Res 2025 — animal study — hydrogen-rich water — positive - Molecular Hydrogen as a Potential Adjunctive Therapy to Improve Renal Function and Reduce Fatigue in an Elderly Patient With Chronic Comorbidities: A Case Report.
In Vivo 2025 — human case report — hydrogen-rich water — positive - Oral Administration of Hydrogen-rich Water: Biomedical Activities, Potential Mechanisms, and Clinical Applications.
Curr Pharm Des 2025 — review — hydrogen-rich water — not assessed - Molecular Hydrogen Modulates T Cell Differentiation and Enhances Neuro-Regeneration in a Vascular Dementia Mouse Model.
Antioxidants (Basel) 2025 — animal study — hydrogen-rich water — positive - Hydrogen-rich water ameliorates imiquimod-induced psoriasis-like skin lesions and regulates macrophage polarization in dyslipidemic ApoE-deficient mice.
Eur J Pharmacol 2025 — animal study — hydrogen-rich water — positive - Long-term consumption of hydrogen-rich water provides hepatoprotection by improving mitochondrial biology and quality control in chronically stressed mice.
PLoS One 2025 — animal study — hydrogen-rich water — positive - Molecular Hydrogen Therapy for SLE-PAH: Case Report on Immune Marker Modulation.
In Vivo 2025 — human case report — hydrogen-rich water — positive - Molecular Hydrogen Therapy Enhances Immune Markers in Treg, Plasma, Tr1 Cells, and KLRG1 Expression on Tc Cells: A Case of Acute SDH With Midline Shift and Uncal Herniation Post-decompressive Craniectomy.
In Vivo 2025 — human case report — hydrogen-rich water — mixed - Aging, vascular dysfunction, and the blood-brain barrier: unveiling the pathophysiology of stroke in older adults.
Biogerontology 2025 — review — hydrogen-rich water — not assessed - Alleviation of salt stress in strawberries by hydrogen-rich water: Physiological, transcriptomic and metabolomic responses.
Physiol Plant 2025 — other — hydrogen-rich water — positive - Effects of Hydrogen-Rich Water on Growth, Redox Homeostasis and Hormonal, Histological and Immune Systems in Rats Exposed to High Cage Density Stress.
Vet Med Sci 2025 — animal study — hydrogen-rich water — positive - Hydrogen-rich water consumption modifies the chemical, biochemical, nutritional, and bioactive properties of the goat's colostrum and mature milk.
Food Chem 2025 — animal study — hydrogen-rich water — mixed - Protective effect of hydrogen-rich water on spermatogenesis in high-fat diet obese rats.
Toxicol Appl Pharmacol 2025 — animal study — hydrogen-rich water — positive - The effect of Hydrogen-rich water on retinal degeneration in the outer nuclear layer of simulated weightlessness rats.
Life Sci Space Res (Amst) 2025 — animal study — hydrogen-rich water — positive - Advanced Glycation End Products and Skin Autoimmune Disorders: Pathogenic Insights into Vitiligo, Bullous Pemphigoid, and Type 1 Diabetes Mellitus.
Curr Med Chem 2025 — review — hydrogen-rich water — not assessed - Molecular Hydrogen Capsule Therapy for Primary Biliary Cholangitis With Elevated IgG4: A Case Report on Immune Marker Normalization.
In Vivo 2025 — human case report — hydrogen-rich water — positive - Corrigendum to "Protective effect of hydrogen-rich water on spermatogenesis in high-fat diet obese rats" [Toxicology and Applied Pharmacology Volume 499, June 2025, 117334].
Toxicol Appl Pharmacol 2025 — other — hydrogen-rich water — not assessed - Molecular Hydrogen Ameliorates Anti-Desmoglein 1 Antibody-Induced Pemphigus-Associated Interstitial Lung Disease by Inhibiting Oxidative Stress.
Int J Mol Sci 2025 — animal study — hydrogen-rich water — positive - Hydrogen-Rich Water Decreases Muscle Damage and Improves Power Endurance in Elite Athletes: A Randomized, Double-Blinded, Placebo-Controlled Trial.
J Lifestyle Med 2025 — human randomized controlled trial — hydrogen-rich water — positive - Treatment with hydrogen-rich water protects against thioacetamide-induced hepatic encephalopathy in rats through stabilizing liver-brain disturbance.
Sci Rep 2025 — animal study — hydrogen-rich water — positive - Hydrogen activates ACOD1-itaconate pathway to ameliorate steroid-associated osteonecrosis.
Biomaterials 2025 — animal study — hydrogen-rich water — positive - Comparison of the Antimicrobial Effect of Hydrogen Water and Chlorhexidine Mouth rinse in Toothbrush Disinfection Among Dental Students.
J Pharm Bioallied Sci 2025 — human randomized controlled trial — hydrogen-rich water — positive - The effects of drinking hydrogen-rich water for six weeks on exercise-related biomarkers in exercise-naïve men and women over 50 years following resistance training program: a randomized controlled pilot trial.
Res Sports Med 2025 — human randomized controlled trial — hydrogen-rich water — positive - Predicting Therapeutic Response to Molecular Hydrogen in Autoimmune Diseases via Immunophenotyping.
APMIS 2025 — human observational study — hydrogen-rich water — mixed - Mechanism of hydrogen-rich water alleviating radiation-induced cognitive impairment through PI3K/AKT/Caspase-9 pathway mediating anti-oxidation.
Mol Cell Biochem 2025 — animal study — hydrogen-rich water — positive - Long-term administration of hydrogen-rich water enhances quality of life in diabetic rats and reduces renal neoplasm incidence through modulation of inflammatory and metabolic pathways.
Transl Androl Urol 2025 — animal study — hydrogen-rich water — positive - Hydrogen-Rich Water Consumption for Acute and Residual Fatigue After Simulated Football Matches: Protocol for a Randomized, Double-Blinded, Placebo-Controlled, Parallel Trial.
JMIR Res Protoc 2025 — other — hydrogen-rich water — not assessed - Pre-Exercise Ingestion of Hydrogen-Rich Cold Water Enhances Endurance Performance and Lactate Response in Heat.
Medicina (Kaunas) 2025 — human randomized controlled trial — hydrogen-rich water — positive - The Effects of 8-Week Hydrogen-Rich Water Consumption on Appetite, Body Composition, Sleep Quality, and Circulating Glucagon-like Peptide-1 in Obese Men and Women (HYDRAPPET): A Randomized Controlled Trial.
Medicina (Kaunas) 2025 — human randomized controlled trial — hydrogen-rich water — positive - Long-Term Neuroprotective Effects of Hydrogen-Rich Water and Memantine in Chronic Radiation-Induced Brain Injury: Behavioral, Histological, and Molecular Insights.
Antioxidants (Basel) 2025 — animal study — hydrogen-rich water — positive - Hydrogen-rich water supplementation attenuates oxidative stress and inflammation in chronic high-altitude disease patients: A double-blind randomized placebo-controlled study.
Food Res Int 2025 — human randomized controlled trial — hydrogen-rich water — mixed - Optimized dose of hydrogen-enriched water with minocycline combination therapy in experimental ischemic stroke.
Brain Res 2025 — animal study — hydrogen-rich water — positive - Adjunctive molecular hydrogen therapy for refractory malar rash in systemic lupus erythematosus: A case report with immunological insights.
SAGE Open Med Case Rep 2025 — human case report — hydrogen-rich water — positive - Molecular hydrogen-rhodiola as an adjuvant therapy for ischemic stroke in internal carotid artery occlusion: A case report.
Open Med (Wars) 2025 — human case report — hydrogen-rich water — positive - Dynamic Immunomodulation by Hydrogen Capsule Therapy in SLE-associated Pulmonary Arterial Hypertension: A Case Report.
In Vivo 2025 — human case report — hydrogen-rich water — positive - Hydrogen-rich water irrigation enhances fruit quality in 'Flame Seedless' grapes by regulating chlorophyll fluorescence parameters and antioxidant activities.
Front Plant Sci 2025 — other — hydrogen-rich water — positive - Synergistic alleviation effects of salt-tolerant plant growth-promoting rhizobacteria and hydrogen-rich water on salt stress in.
Front Plant Sci 2025 — other — hydrogen-rich water — positive - Does Hydrogen-Rich Water Reduce Oxidative Stress in Patients with Chronic Mountain Sickness? A Randomized, Blinded, Controlled Trial.
High Alt Med Biol 2025 — human randomized controlled trial — hydrogen-rich water — mixed - Hydrogen-Rich Water Potentiates Cannabinoid- and Gabapentinoid-Induced Analgesia in Neuropathic Pain.
Int J Mol Sci 2025 — animal study — hydrogen-rich water — positive - Hydrogen-rich water attenuates radiation-induced oral mucositis in mice via antioxidant and gut microbiota-stabilizing effects: a longitudinal study.
Gut Microbes Rep 2025 — animal study — hydrogen-rich water — positive - Hydrogen Water: Extra Healthy or a Hoax?-A Systematic Review.
Int J Mol Sci 2024 — meta-analysis — hydrogen-rich water — mixed - Hydrogen-rich water improves sleep consolidation and enhances forebrain neuronal activation in mice.
Sleep Adv 2024 — animal study — hydrogen-rich water — positive - A preliminary therapeutic study of the effects of molecular hydrogen on intestinal dysbiosis and small intestinal injury in high-fat diet-loaded senescence-accelerated mice.
Nutrition 2024 — animal study — hydrogen-rich water — positive - Hydrogen-rich water supplementation improves metabolic profile during peripartum period in Gurcu goats and enhances the health and survival of kids.
Res Vet Sci 2024 — animal study — hydrogen-rich water — mixed - Decoupling the mutual promotion of inflammation and oxidative stress mitigates cognitive decline and depression-like behavior in rmTBI mice by promoting myelin renewal and neuronal survival.
Biomed Pharmacother 2024 — animal study — hydrogen-rich water — positive - The effect of hydrogen-rich water consumption on premenstrual symptoms and quality of life: a randomized controlled trial.
BMC Womens Health 2024 — human randomized controlled trial — hydrogen-rich water — positive - Health Benefits of Electrolyzed Hydrogen Water: Antioxidant and Anti-Inflammatory Effects in Living Organisms.
Antioxidants (Basel) 2024 — review — hydrogen-rich water — not assessed - Hydrogen-rich water supplementation promotes muscle recovery after two strenuous training sessions performed on the same day in elite fin swimmers: randomized, double-blind, placebo-controlled, crossover trial.
Front Physiol 2024 — human randomized controlled trial — hydrogen-rich water — positive - The Effect of 14-Day Consumption of Hydrogen-Rich Water Alleviates Fatigue but Does Not Ameliorate Dyspnea in Long-COVID Patients: A Pilot, Single-Blind, and Randomized, Controlled Trial.
Nutrients 2024 — human randomized controlled trial — hydrogen-rich water — mixed - Hydrogen-rich water alleviates constipation by attenuating oxidative stress through the sirtuin1/nuclear factor-erythroid-2-related factor 2/heme oxygenase-1 signaling pathway.
World J Gastroenterol 2024 — animal study — hydrogen-rich water — positive - The GA and ABA signaling is required for hydrogen-mediated seed germination in wax gourd.
BMC Plant Biol 2024 — other — hydrogen-rich water — positive - Mitigating radiation-induced brain injury via NLRP3/NLRC4/Caspase-1 pyroptosis pathway: Efficacy of memantine and hydrogen-rich water.
Biomed Pharmacother 2024 — animal study — hydrogen-rich water — positive - Hydrogen-Rich Alkaline Water Supplementation Restores a Healthy State and Redox Balance in HO-Treated Mice.
Int J Mol Sci 2024 — animal study — hydrogen-rich water — positive - Hydrogen nanobubbles and oxidative windows: Investigating how varying hydrogen concentrations influence seed germination and stress defense.
J Hazard Mater 2024 — in vitro study — hydrogen-rich water — mixed - Hydrogen alleviates hypoxic-ischaemic brain damage in neonatal rats by inhibiting injury of brain pericytes.
J Cell Mol Med 2024 — animal study — hydrogen-rich water — positive - The Combination of Molecular Hydrogen and Heme Oxygenase 1 Effectively Inhibits Neuropathy Caused by Paclitaxel in Mice.
Antioxidants (Basel) 2024 — animal study — hydrogen-rich water — positive - Molecular Hydrogen for Outpatients with COVID-19 (Hydro-COVID): A Phase 3 Randomised, Triple-Blinded, Pragmatic, Placebo-Controlled, Multicentre Trial.
J Clin Med 2024 — human randomized controlled trial — hydrogen-rich water — null - Hydrogen-rich water alleviates asthma airway inflammation by modulating tryptophan metabolism and activating aryl hydrocarbon receptor via gut microbiota regulation.
Free Radic Biol Med 2024 — animal study — hydrogen-rich water — positive - Molecular hydrogen supplementation in mice ameliorates lipopolysaccharide-induced loss of interest.
PCN Rep 2024 — animal study — hydrogen-rich water — mixed - Effects of hydrogen-rich water on blood uric acid in patients with hyperuricemia: A randomized placebo-controlled trial.
Heliyon 2024 — human randomized controlled trial — hydrogen-rich water — positive - Using oral molecular hydrogen supplements to combat microinflammation in humans: a pilot observational study.
Int J Med Sci 2024 — human observational study — hydrogen-rich water — positive - Effects of 8 days intake of hydrogen-rich water on muscular endurance performance and fatigue recovery during resistance training.
Front Physiol 2024 — human randomized controlled trial — hydrogen-rich water — mixed - Oral Intake of Hydrogen Water Improves Retinal Blood Flow Dysregulation in Response to Flicker Stimulation and Systemic Hyperoxia in Diabetic Mice.
Transl Vis Sci Technol 2024 — animal study — hydrogen-rich water — positive - Molecular Hydrogen Therapy in Sjögren's Syndrome With Pulmonary Arterial Hypertension and Right-sided Heart Failure: A Case Report of Improved Immune Markers Including Treg, B Cells and Plasma Cell.
In Vivo 2024 — human case report — hydrogen-rich water — positive - Molecular Hydrogen Therapy in Aneurysmal SAH With RA and Newly-diagnosed SLE, Complicated With Acute Ischemic Infarction: A Case Report of Improved Immune Markers Including Tr1 Cells, Breg Cells and TIM3 Expression on Tc Cells.
In Vivo 2024 — human case report — hydrogen-rich water — positive - Hydrogen-rich water 400ppb as a potential strategy for improving ruminant nutrition and mitigating methane emissions.
BMC Microbiol 2024 — in vitro study — hydrogen-rich water — positive - Combating oxidative stress and inflammation in gentamicin-induced nephrotoxicity using hydrogen-rich water.
Tissue Cell 2024 — animal study — hydrogen-rich water — positive - Regulation of hydrogen rich water on strawberry seedlings and root endophytic bacteria under salt stress.
Front Plant Sci 2024 — other — hydrogen-rich water — positive - Therapeutic potential of hydrogen-rich water in zebrafish model of Alzheimer's disease: targeting oxidative stress, inflammation, and the gut-brain axis.
Front Aging Neurosci 2024 — animal study — hydrogen-rich water — positive - The Effects of Hydrogen-Rich Water on Blood Lipid Profiles in Metabolic Disorders Clinical Trials: A Systematic Review and Meta-analysis.
Int J Endocrinol Metab 2024 — meta-analysis — hydrogen-rich water — mixed - The impact of hydrogen-rich water on liver enzyme levels in clinical populations: a comprehensive review and meta-analysis.
Gastroenterol Hepatol Bed Bench 2024 — meta-analysis — hydrogen-rich water — positive - Hydrogen-rich water delays fruit softening and prolongs shelf life of postharvest okras.
Food Chem 2023 — other — hydrogen-rich water — positive - Hydrogen-rich water alleviates chilling injury-induced lignification of kiwifruit by inhibiting peroxidase activity and improving antioxidant system.
J Sci Food Agric 2023 — other — hydrogen-rich water — positive - Ameliorating Role of Hydrogen-Rich Water Against NSAID-Induced Enteropathy via Reduction of ROS and Production of Short-Chain Fatty Acids.
Dig Dis Sci 2023 — animal study — hydrogen-rich water — positive - Taurine, Coenzyme Q, and Hydrogen Water Prevents Germanium Dioxide-Induced Mitochondrial Dysfunction and Associated Sensorineural Hearing Loss in mouse.
Hear Res 2023 — animal study — hydrogen-rich water — positive - Transcriptomic and metabolomic studies on the protective effect of molecular hydrogen against nuclear electromagnetic pulse-induced brain damage.
Front Public Health 2023 — animal study — hydrogen-rich water — positive - Molecular Hydrogen Prevents Osteoclast Activation in a Glucocorticoid-Induced Osteoporosis Zebrafish Scale Model.
Antioxidants (Basel) 2023 — animal study — hydrogen-rich water — mixed - Hydrogen-rich water treatment increased several phytohormones and prolonged the shelf life in postharvest okras.
Front Plant Sci 2023 — other — hydrogen-rich water — positive - Novel therapeutic approaches based on the pathological role of gut dysbiosis on the link between nonalcoholic fatty liver disease and insulin resistance.
Eur Rev Med Pharmacol Sci 2023 — review — hydrogen-rich water — not assessed
Related safety notes
Cite as: H2 Papers — https://h2-papers.org/en/topics/hydrogen-water/evidence