水素水が急性鉛曝露ラットの肝臓・腎臓・精巣毒性に及ぼす保護効果
Lead acetate (PbA) exposure causes multi-organ damage through oxidative stress, mitochondrial dysfunction, and inflammation. In this animal study, 30 male Wistar rats were allocated to five groups—control, PbA, EDTA, hydrogen-rich water (HRW), and HRW+EDTA—and assessed after one week for body weight, organ weights, serum biochemistry, histopathology, and oxidative stress markers (MDA, SOD, catalase) in liver, kidney, and testis. PbA induced approximately 13% body weight loss, roughly doubled serum creatinine and liver enzymes, elevated tissue MDA, and reduced antioxidant enzyme activity. HRW alone significantly lowered MDA and restored catalase activity in liver and testis. EDTA alone reduced hepatic MDA by approximately 30% but did not recover antioxidant enzyme activity. The combined HRW+EDTA regimen reduced MDA but yielded lower catalase activity than HRW alone, and SOD showed no consistent recovery across any group. These findings indicate that HRW confers statistically significant organ-protective effects against acute lead toxicity, with catalase restoration appearing to be a key contributing mechanism.
HRW is proposed to suppress mitochondrial reactive oxygen species production, thereby reducing lipid peroxidation (MDA) and restoring catalase activity in liver and testis, which collectively mitigates lead-induced oxidative organ damage.
Hydrogen-rich water is a low-risk delivery route, but the achievable systemic hydrogen dose is bounded. For clinical applications, inhalation is the most efficient route; inhalation, however, carries explosion risk, and concentration matters (empirical LFL of 10% applies to inhalation environments; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).
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https://h2-papers.org/en/papers/42115396