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Safety Notes
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heavy metal toxicity
25 papers
Delivery-method distribution
hydrogen-rich water: 18
in vitro: 5
not specified: 1
injection / infusion: 1
Protective effects of hydrogen-rich water against acute lead-induced hepatic, renal, and testicular toxicity in rats.
2026 ・ Naunyn Schmiedebergs Arch Pharmacol ・ PMID 42115396
hydrogen-rich water
positive
animal study
Enhanced phytoremediation of Cd-As co-contaminated farmland using hydrogen-rich water: Mechanisms and efficiency evaluation in Solanum nigrum L․.
2026 ・ J Environ Sci (China) ・ PMID 41765536
hydrogen-rich water
positive
other
Di-chlorido-{()-,-dimethyl-2-[phen-yl(pyridin-2-yl)methyl-idene]hydrazine-1-carbo-thio-amide}cadmium(II).
2025 ・ IUCrdata ・ PMID 40487503
not specified
not assessed
other
Mitigating environmental toxicity with hydrogen nanobubbles: A mitochondrial function-based approach to ecological restoration.
2024 ・ Environ Int ・ PMID 39515037
in vitro
positive
in vitro study
Hydrogen nanobubbles and oxidative windows: Investigating how varying hydrogen concentrations influence seed germination and stress defense.
2024 ・ J Hazard Mater ・ PMID 38941838
hydrogen-rich water
mixed
in vitro study
Integration of metal organic framework nanoparticles into sodium alginate biopolymer-based three-dimensional membrane capsules for the efficient removal of toxic metal cations from water and real sewage.
2024 ・ Int J Biol Macromol ・ PMID 38582471
in vitro
not assessed
in vitro study
Electrolyzed-Reduced Water: Review II: Safety Concerns and Effectiveness as a Source of Hydrogen Water.
2022 ・ Int J Mol Sci ・ PMID 36498838
hydrogen-rich water
mixed
review
Magnesium hydride confers copper tolerance in alfalfa via regulating nitric oxide signaling.
2022 ・ Ecotoxicol Environ Saf ・ PMID 35032725
in vitro
positive
other
Evaluation of the hydrogen-rich water alleviation potential on mercury toxicity in earthworms using ATR-FTIR and LC-ESI-MS/MS spectroscopy.
2022 ・ Environ Sci Pollut Res Int ・ PMID 34718956
injection / infusion
positive
animal study
Hydrogen-Rich Water Alleviates the Nickel-Induced Toxic Responses (Inflammatory Responses, Oxidative Stress, DNA Damage) and Ameliorates Cocoon Production in Earthworm.
2022 ・ Biol Trace Elem Res ・ PMID 34482505
hydrogen-rich water
positive
animal study
Molecular hydrogen in agriculture.
2021 ・ Planta ・ PMID 34420086
hydrogen-rich water
not assessed
review
Application of hydrogen-rich water modulates physio-biochemical functions and early growth of fragrant rice under Cd and Pb stress.
2021 ・ Environ Sci Pollut Res Int ・ PMID 34114146
hydrogen-rich water
positive
other
Transcriptome analysis reveals insight into molecular hydrogen-induced cadmium tolerance in alfalfa: the prominent role of sulfur and (homo)glutathione metabolism.
2020 ・ BMC Plant Biol ・ PMID 32019510
hydrogen-rich water
positive
in vitro study
Hydrogen gas alleviates toxic effects of cadmium in Brassica campestris seedlings through up-regulation of the antioxidant capacities: Possible involvement of nitric oxide.
2019 ・ Environ Pollut ・ PMID 31071632
hydrogen-rich water
positive
in vitro study
Hydrogen gas promotes the adventitious rooting in cucumber under cadmium stress.
2019 ・ PLoS One ・ PMID 30785953
hydrogen-rich water
positive
in vitro study
Intestinal Microbiota Ecological Response to Oral Administrations of Hydrogen-Rich Water and Lactulose in Female Piglets Fed aToxin-Contaminated Diet.
2018 ・ Toxins (Basel) ・ PMID 29914163
hydrogen-rich water
positive
animal study
Hydrogen-Rich Water and Lactulose Protect Against Growth Suppression and Oxidative Stress in Female Piglets FedToxins Contaminated Diets.
2018 ・ Toxins (Basel) ・ PMID 29867031
hydrogen-rich water
positive
animal study
Structural and lipid peroxidation effects of lead on rat hippocampus and its attenuation by hydrogen rich water.
2018 ・ J Chem Neuroanat ・ PMID 29694843
hydrogen-rich water
positive
animal study
Hydrogen-rich water alleviates the toxicities of different stresses to mycelial growth in Hypsizygus marmoreus.
2017 ・ AMB Express ・ PMID 28565883
in vitro
positive
in vitro study
Proteomic analysis provides insights into the molecular bases of hydrogen gas-induced cadmium resistance in Medicago sativa.
2017 ・ J Proteomics ・ PMID 27989938
hydrogen-rich water
positive
in vitro study
Cadmium-Induced Hydrogen Accumulation Is Involved in Cadmium Tolerance in Brassica campestris by Reestablishment of Reduced Glutathione Homeostasis.
2015 ・ PLoS One ・ PMID 26445361
hydrogen-rich water
positive
in vitro study
Hydrogen-rich water enhances cadmium tolerance in Chinese cabbage by reducing cadmium uptake and increasing antioxidant capacities.
2015 ・ J Plant Physiol ・ PMID 25543863
in vitro
positive
other
Hydrogen-rich water confers plant tolerance to mercury toxicity in alfalfa seedlings.
2014 ・ Ecotoxicol Environ Saf ・ PMID 24793520
hydrogen-rich water
positive
in vitro study
Hydrogen-rich water alleviates aluminum-induced inhibition of root elongation in alfalfa via decreasing nitric oxide production.
2014 ・ J Hazard Mater ・ PMID 24413050
hydrogen-rich water
positive
in vitro study
Alleviation of cadmium toxicity in Medicago sativa by hydrogen-rich water.
2013 ・ J Hazard Mater ・ PMID 23846121
hydrogen-rich water
positive
in vitro study