水素水摂取による放射線誘発性口腔粘膜炎の軽減：抗酸化作用と腸内細菌叢安定化を介したマウス縦断研究
In a mouse model of head and neck irradiation, pronounced epithelial damage was observed in both oral and intestinal mucosa, accompanied by reduced expression of tight junction proteins occludin and ZO-1 in colonic tissue. Administration of hydrogen-rich water (HW) significantly lowered the severity of oral lesions, maintained epithelial thickness, and restored colonic tight junction protein levels. Fecal 16S rRNA sequencing revealed that irradiation alone caused expansion of potentially pathogenic bacterial taxa alongside depletion of short-chain fatty acid-producing families, including Lachnospiraceae and Ruminococcaceae. HW supplementation partially reversed these microbial alterations, and this reversal correlated with reductions in oral inflammatory markers. Collectively, the data support an oral-gut axis model in which HW promotes mucosal recovery through microbiome stabilization and attenuation of oxidative and inflammatory stress following craniofacial irradiation.
Hydrogen-rich water scavenges reactive oxygen species and stabilizes gut microbiota composition, preserving short-chain fatty acid-producing bacteria and thereby protecting the oral-intestinal mucosal barrier against radiation-induced damage.
Hydrogen-rich water is a low-risk delivery route, but the achievable systemic hydrogen dose is bounded. For clinical applications, inhalation is the most efficient route; inhalation, however, carries explosion risk, and concentration matters (empirical LFL of 10% applies to inhalation environments; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).
See also:
https://h2-papers.org/en/papers/41909889