核電磁パルス誘発性脳損傷に対する分子状水素の保護効果：トランスクリプトーム・メタボローム統合解析
Using a rat model exposed to nuclear electromagnetic pulse (NEMP; field intensity 400 kV/m, 20 ns rise time, 200 ns pulse width), this study examined whether hydrogen-rich water (HRW) administered from 3 days before exposure could reduce brain injury. Behavioral assessments one day post-exposure showed that NEMP-induced anxiety-like responses in the elevated plus maze and open field test were substantially reduced in HRW-treated animals. Histopathological examination at 7 days confirmed attenuation of neuronal damage in the hippocampus and amygdala. Transcriptomic profiling revealed marked disruption of microtubule-related gene expression following NEMP exposure. Combined transcriptomic and metabolomic analysis identified neuroactive ligand-receptor interaction, the synaptic vesicle cycle, and glutathione metabolic pathways as central to both NEMP-induced damage and the protective action of molecular hydrogen.
Molecular hydrogen scavenges intracellular hydroxyl radicals and modulates the glutathione metabolic pathway, exerting antioxidant, anti-apoptotic, and anti-inflammatory effects. Additionally, regulation of the synaptic vesicle cycle and neuroactive ligand-receptor interactions appears to contribute to neuroprotection against NEMP-induced injury.
Hydrogen-rich water is a low-risk delivery route, but the achievable systemic hydrogen dose is bounded. For clinical applications, inhalation is the most efficient route; inhalation, however, carries explosion risk, and concentration matters (empirical LFL of 10% applies to inhalation environments; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).
See also:
https://h2-papers.org/en/papers/36817910