水素水の長期投与が糖尿病ラットの生活の質を改善し腎腫瘍発生率を低下させる：炎症・代謝経路の調節機序
Using a streptozotocin (STZ)-induced diabetic rat model, this study examined the effects of 24-week oral hydrogen-rich water (HRW) administration across multiple organ systems via RNA sequencing. HRW-treated animals showed significant reductions in fasting blood glucose and increases in body weight compared with controls. Histological assessment of eyes, testes, penis, sperm, liver, kidneys, stomach, colon, and bone revealed attenuation of diabetic cataracts, bone loss, nephropathy, erectile dysfunction, asthenozoospermia, and renal neoplasms. Transcriptomic profiling of testis, liver, kidney, and stomach tissues identified substantial enrichment of metabolic pathway-related differentially expressed genes, indicating metabolic reprogramming as a central mechanism. These findings suggest that sustained HRW consumption may offer a safe and practical approach to improving systemic metabolic health and reducing complication burden in diabetes.
HRW modulates expression of inflammation- and metabolism-related genes across testis, liver, kidney, and stomach tissues, leading to metabolic pathway reprogramming that underlies reductions in blood glucose and attenuation of multiple diabetic complications.
Hydrogen-rich water is a low-risk delivery route, but the achievable systemic hydrogen dose is bounded. For clinical applications, inhalation is the most efficient route; inhalation, however, carries explosion risk, and concentration matters (empirical LFL of 10% applies to inhalation environments; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).
See also:
https://h2-papers.org/en/papers/40687659