BOLD MRIを用いたシスプラチン誘発腎毒性に対する水素水の保護効果の検討
This animal study examined whether hydrogen-rich water (HW) could mitigate cisplatin (CP)-induced kidney damage in rats, using blood oxygenation level-dependent (BOLD) MRI as a functional imaging tool. Twenty-eight rats were divided into four groups: control (standard water, no CP), CP only, CP with HW, and HW only. Apparent transverse relaxation rate (R2) values were derived from T2-weighted images. On days 4 and 7, the renal medullary R2 values normalized to baseline were significantly elevated in the CP+HW group compared with the CP-only group. Serum creatinine and blood urea nitrogen levels were markedly higher in the CP group than in the control, CP+HW, and HW groups, indicating that HW preserved renal function. The authors attribute the observed protective effect to scavenging of cytotoxic oxygen radicals by molecular hydrogen. BOLD MRI was found to be a potentially useful modality for monitoring CP-induced nephrotoxicity.
Molecular hydrogen in hydrogen-rich water is thought to scavenge cytotoxic oxygen radicals generated by cisplatin, thereby preserving renal medullary oxygenation and reducing functional kidney impairment as reflected by normalized R2 values and lower creatinine/BUN levels.
Hydrogen-rich water is a low-risk delivery route, but the achievable systemic hydrogen dose is bounded. For clinical applications, inhalation is the most efficient route; inhalation, however, carries explosion risk, and concentration matters (empirical LFL of 10% applies to inhalation environments; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).
See also:
https://h2-papers.org/en/papers/21882093