分子状水素と腎疾患：計量書誌学およびデータ解析に基づくスコーピングレビュー
Acute kidney injury and chronic kidney disease represent major global health burdens. This scoping review, conducted according to PRISMA-ScR guidelines, identified 69 publications from Scopus and Web of Science to examine the renoprotective potential of molecular hydrogen (H2). A combined quantitative bibliometric and qualitative thematic approach—uncommon in conventional scoping reviews—was employed. Most publications originated from Asian countries, predominantly China and Japan, with notable activity peaks in 2019 and 2024, though international collaboration remained sparse. Across models of acute kidney injury, nephrotoxicity, transplantation, and early chronic kidney disease, H2 consistently exhibited protective effects against apoptosis, fibrosis, inflammation, and oxidative stress. The review highlights significant research gaps, including the scarcity of robust clinical trials and the absence of standardized methodologies, which currently limit translation into routine nephrology practice.
H2 is proposed to exert renoprotective effects through selective scavenging of reactive oxygen species, suppression of inflammatory signaling, and inhibition of apoptotic pathways, collectively reducing fibrosis and oxidative damage in renal tissue.
This study combines multiple delivery routes. As a general principle, the most efficient route for routine hydrogen intake is inhalation. Inhalation carries explosion risk (empirical LFL of 10%; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).
See also:
https://h2-papers.org/en/papers/40826940