高脂肪食負荷老化促進マウスにおける腸内細菌叢異常および小腸傷害に対する分子状水素の影響に関する予備的検討
This animal study examined the combined effects of aging and high-fat diet (HFD) on gut microbiota composition and small intestinal integrity, and assessed whether hydrogen-rich jelly (HRJ) could ameliorate these changes. Senescence-accelerated SAMP8 mice and control SAMR1 mice received either a normal diet or HFD for 10 weeks, followed by 4 weeks of placebo or HRJ supplementation. HFD feeding in SAMP8 mice reduced CDX2 and BrdU expression while elevating malondialdehyde (MDA) levels in small intestinal tissue, indicating oxidative damage and impaired epithelial renewal. HRJ administration reversed these alterations. Cecal microbiota profiling via 16S rRNA sequencing identified 283 bacterial genera; Parvibacter abundance correlated positively with both HFD and aging, while 10 genera including Anaerofustis, Butyricicoccus, and Ruminococcus showed negative correlations. HRJ shifted microbiota composition by increasing Lactinobactor and reducing Akkermansia, Gracilibacter, and Marvinbryantia. These findings indicate that molecular hydrogen may modulate gut microbial ecology and attenuate HFD-associated small intestinal injury in aged mice.
Hydrogen-rich jelly intake suppressed lipid peroxidation (reduced MDA elevation), restored CDX2-mediated epithelial differentiation and BrdU-marked cell proliferation in the small intestine, and shifted cecal microbiota composition, suggesting antioxidant and microbiome-modulatory mechanisms.
Hydrogen-rich water is a low-risk delivery route, but the achievable systemic hydrogen dose is bounded. For clinical applications, inhalation is the most efficient route; inhalation, however, carries explosion risk, and concentration matters (empirical LFL of 10% applies to inhalation environments; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).
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https://h2-papers.org/en/papers/38428218