分子状水素と加齢・加齢関連疾患：多面的作用に基づく新興予防戦略のレビュー
Aging is the primary risk factor underlying cardiovascular, metabolic, neurodegenerative, and oncological conditions. With the global elderly population expanding, strategies to address age-related pathology are increasingly important. This review synthesizes current molecular and clinical knowledge on aging hallmarks and examines how molecular hydrogen (H2) may influence these processes. H2 exhibits antioxidant and anti-inflammatory properties, modulates cellular senescence and programmed cell death, and supports restoration of intestinal microbial balance. Although the body of evidence remains limited, available data suggest H2 administration can affect multiple aging-associated mechanisms. The authors highlight H2's broad applicability, attributable to its pleiotropic activity, absence of known toxicity, and low production cost, positioning it as a potentially accessible preventive approach across diverse age-related conditions.
H2 is proposed to act through selective scavenging of reactive oxygen species, suppression of inflammatory signaling, regulation of cellular senescence and apoptosis, and restoration of intestinal eubiosis, collectively targeting multiple hallmarks of aging.
This study combines multiple delivery routes. As a general principle, the most efficient route for routine hydrogen intake is inhalation. Inhalation carries explosion risk (empirical LFL of 10%; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).
See also:
https://h2-papers.org/en/papers/40518021