代謝疾患における水素水の血中脂質プロファイルへの影響：ランダム化比較試験の系統的レビューとメタ解析
A systematic review and meta-analysis was conducted to assess how hydrogen-rich water (HRW) affects serum lipid parameters in patients with metabolic disorders. Following PRISMA guidelines, eight randomized controlled trials totaling 357 participants were identified from PubMed, Web of Science, Embase, and Google Scholar (up to January 2024). Pooled analysis revealed modest reductions in triglycerides (95% CI: −0.27 [−0.47, −0.07]) and total cholesterol (95% CI: −0.07 [−0.32, −0.18]), while LDL showed a slight non-significant decrease (95% CI: −0.06 [−0.28, 0.15]). HDL levels exhibited notable heterogeneity across studies (I² = 37.32%). Meta-regression indicated that intervention duration positively moderated outcomes. All included studies demonstrated low or negligible risk of bias based on Jadad scoring. The findings suggest that HRW produces modest lipid-lowering effects, though inconsistencies in HDL responses underscore the need for larger, longer-duration trials.
HRW is proposed to modulate lipid peroxidation and inflammatory responses, thereby contributing to modest reductions in circulating triglyceride and total cholesterol levels in individuals with metabolic dysfunction.
Hydrogen-rich water is a low-risk delivery route, but the achievable systemic hydrogen dose is bounded. For clinical applications, inhalation is the most efficient route; inhalation, however, carries explosion risk, and concentration matters (empirical LFL of 10% applies to inhalation environments; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).
See also:
https://h2-papers.org/en/papers/39839806