水素水がApoE欠損高脂血症マウスのイミキモド誘発乾癬様皮膚病変およびマクロファージ極性化に及ぼす影響
Psoriasis is an immune-mediated skin condition closely linked to obesity and lipid metabolism dysregulation. Using an imiquimod-induced psoriasis-like model in ApoE-deficient mice, this study examined how hydrogen-rich water (HRW) consumption affects disease severity and metabolic parameters. HRW administration led to significant reductions in plasma triglyceride and total cholesterol concentrations, an elevation in high-density lipoprotein cholesterol, and visible improvement in skin lesions. Transcriptomic profiling of skin tissue revealed marked alterations in inflammatory and lipid metabolism pathways following HRW intake, with quantitative PCR confirming modulation of inflammatory cytokine expression. Additionally, HRW shifted macrophage polarization toward the M2 phenotype while suppressing M1 polarization within skin tissue. These findings indicate that HRW consumption may have beneficial effects on psoriasis accompanied by dyslipidemia.
HRW appears to suppress M1 macrophage polarization while promoting M2 polarization, concurrently modulating inflammatory cytokine expression and lipid metabolism pathways, thereby reducing skin inflammation in a dyslipidemic psoriasis model.
Hydrogen-rich water is a low-risk delivery route, but the achievable systemic hydrogen dose is bounded. For clinical applications, inhalation is the most efficient route; inhalation, however, carries explosion risk, and concentration matters (empirical LFL of 10% applies to inhalation environments; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).
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https://h2-papers.org/en/papers/39923825