H₂
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Safety Notes
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oxidative stress
899 papers
Delivery-method distribution
hydrogen-rich water: 313
inhalation: 153
mixed routes: 150
in vitro: 103
injection / infusion: 72
not specified: 66
topical application: 19
animal model: 15
hydrogen bath: 8
H(2) gas improves functional outcome after cardiac arrest to an extent comparable to therapeutic hypothermia in a rat model.
2012 ・ J Am Heart Assoc ・ PMID 23316300
inhalation
positive
animal study
Combination therapy with molecular hydrogen and hyperoxia in a murine model of polymicrobial sepsis.
2012 ・ Shock ・ PMID 23160520
inhalation
positive
animal study
Consumption of water containing a high concentration of molecular hydrogen reduces oxidative stress and disease activity in patients with rheumatoid arthritis: an open-label pilot study.
2012 ・ Med Gas Res ・ PMID 23031079
hydrogen-rich water
positive
human observational study
Protective effects of hydrogen-rich saline in a rat model of permanent focal cerebral ischemia via reducing oxidative stress and inflammatory cytokines.
2012 ・ Brain Res ・ PMID 23010312
injection / infusion
positive
animal study
A basic study on molecular hydrogen (H2) inhalation in acute cerebral ischemia patients for safety check with physiological parameters and measurement of blood H2 level.
2012 ・ Med Gas Res ・ PMID 22916706
inhalation
positive
human case report
Hydrogen-supplemented drinking water protects cardiac allografts from inflammation-associated deterioration.
2012 ・ Transpl Int ・ PMID 22891787
hydrogen-rich water
positive
animal study
Molecular hydrogen reduces LPS-induced neuroinflammation and promotes recovery from sickness behaviour in mice.
2012 ・ PLoS One ・ PMID 22860058
hydrogen-rich water
positive
animal study
Therapeutic effects of hydrogen saturated saline on rat diabetic model and insulin resistant model via reduction of oxidative stress.
2012 ・ Chin Med J (Engl) ・ PMID 22800834
injection / infusion
positive
animal study
Hydrogen-rich water inhibits glucose and α,β -dicarbonyl compound-induced reactive oxygen species production in the SHR.Cg-Leprcp/NDmcr rat kidney.
2012 ・ Med Gas Res ・ PMID 22776773
hydrogen-rich water
positive
animal study
Molecular hydrogen as an emerging therapeutic medical gas for neurodegenerative and other diseases.
2012 ・ Oxid Med Cell Longev ・ PMID 22720117
mixed routes
not assessed
review
Hydrogen(H2) treatment for acute erythymatous skin diseases. A report of 4 patients with safety data and a non-controlled feasibility study with H2 concentration measurement on two volunteers.
2012 ・ Med Gas Res ・ PMID 22607973
mixed routes
positive
human case report
Hydrogen-rich water prevents lipid deposition in the descending aorta in a rat periodontitis model.
2012 ・ Arch Oral Biol ・ PMID 22607937
hydrogen-rich water
positive
animal study
Beneficial effect of hydrogen-rich saline on cerebral vasospasm after experimental subarachnoid hemorrhage in rats.
2012 ・ J Neurosci Res ・ PMID 22589232
injection / infusion
positive
animal study
Molecular hydrogen and radiation protection.
2012 ・ Free Radic Res ・ PMID 22537465
mixed routes
positive
review
Pilot study: Effects of drinking hydrogen-rich water on muscle fatigue caused by acute exercise in elite athletes.
2012 ・ Med Gas Res ・ PMID 22520831
hydrogen-rich water
positive
human randomized controlled trial
Molecular hydrogen ameliorates lipopolysaccharide-induced acute lung injury in mice through reducing inflammation and apoptosis.
2012 ・ Shock ・ PMID 22508291
mixed routes
positive
animal study
Hydrogen-rich water prevents progression of nonalcoholic steatohepatitis and accompanying hepatocarcinogenesis in mice.
2012 ・ Hepatology ・ PMID 22505328
hydrogen-rich water
positive
animal study
Protective effects of hydrogen-rich saline in a rat model of traumatic brain injury via reducing oxidative stress.
2012 ・ J Surg Res ・ PMID 22475349
injection / infusion
positive
animal study
Hydrogen-rich saline protects immunocytes from radiation-induced apoptosis.
2012 ・ Med Sci Monit ・ PMID 22460088
injection / infusion
positive
animal study
Inhalation of hydrogen gas attenuates ouabain-induced auditory neuropathy in gerbils.
2012 ・ Acta Pharmacol Sin ・ PMID 22388074
inhalation
positive
animal study
Hydrogen-rich saline protects spermatogenesis and hematopoiesis in irradiated BALB/c mice.
2012 ・ Med Sci Monit ・ PMID 22367121
injection / infusion
positive
animal study
Hydrogen gas ameliorates oxidative stress in early brain injury after subarachnoid hemorrhage in rats.
2012 ・ Crit Care Med ・ PMID 22336722
inhalation
positive
animal study
Oral intake of hydrogen-rich water inhibits intimal hyperplasia in arterialized vein grafts in rats.
2012 ・ Cardiovasc Res ・ PMID 22287575
hydrogen-rich water
positive
animal study
Hydrogen-rich saline protects retina against glutamate-induced excitotoxic injury in guinea pig.
2012 ・ Exp Eye Res ・ PMID 22154552
injection / infusion
positive
animal study
Hydrogen-rich saline prevents neointima formation after carotid balloon injury by suppressing ROS and the TNF-α/NF-κB pathway.
2012 ・ Atherosclerosis ・ PMID 22153150
injection / infusion
positive
animal study
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