水素水摂取が2型糖尿病および耐糖能異常患者の脂質・糖代謝に与える影響：無作為化二重盲検クロスオーバー試験
A randomized, double-blind, placebo-controlled crossover study enrolled 30 patients with diet- and exercise-managed type 2 diabetes mellitus (T2DM) and 6 patients with impaired glucose tolerance (IGT). Participants consumed 900 mL/day of hydrogen-rich water or placebo water for 8 weeks, separated by a 12-week washout. Hydrogen-rich water was associated with significant reductions in modified LDL cholesterol (−15.5%, P<0.01), small dense LDL (−5.7%, P<0.05), and urinary 8-isoprostanes (−6.6%, P<0.05). Trends toward lower oxidized LDL and free fatty acids, and higher adiponectin and extracellular superoxide dismutase were also observed. Notably, 4 of 6 IGT patients showed normalization of oral glucose tolerance test results after hydrogen-rich water intake, suggesting a potential role in reducing insulin resistance and metabolic oxidative burden.
Hydrogen's reducing properties are thought to scavenge reactive oxygen species, thereby decreasing lipid peroxidation markers such as modified LDL and urinary 8-isoprostanes, and attenuating oxidative stress-driven insulin resistance.
Hydrogen-rich water is a low-risk delivery route, but the achievable systemic hydrogen dose is bounded. For clinical applications, inhalation is the most efficient route; inhalation, however, carries explosion risk, and concentration matters (empirical LFL of 10% applies to inhalation environments; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).
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https://h2-papers.org/en/papers/19083400