飽和水素生理食塩水による高酸素誘発性肺障害の軽減効果
This animal study examined whether hydrogen-saturated saline could reduce pulmonary damage caused by exposure to greater than 98% oxygen at 2.5 atmospheres absolute (ATA) for five hours in adult male Sprague-Dawley rats. Animals were allocated to three groups: untreated control, normal saline, and hydrogen-saturated saline. Outcome measures included histological assessment via hematoxylin and eosin staining, lung wet-to-dry weight ratio, bronchoalveolar lavage fluid (BALF) protein concentration and total cell count, and lactate dehydrogenase (LDH) activity in both serum and BALF. Compared with the saline group, hydrogen-saturated saline administration resulted in reduced pulmonary edema, lower LDH activity in serum and BALF, and decreased total cell counts and protein levels in BALF. These findings indicate that hydrogen-saturated saline can mitigate hyperoxia-induced lung injury, with oxidative damage suppression identified as a contributing mechanism.
Molecular hydrogen diffuses rapidly into tissues and cells, scavenging reactive oxygen species and thereby suppressing oxidative damage responsible for hyperoxia-induced alveolar edema, hemorrhage, and cellular injury.
Intravenous hydrogen-saline infusion is a clinic-only route and is not viable for everyday self-administration. For routine hydrogen intake, inhalation is the most practical route, but inhalation carries explosion risk and concentration matters (empirical LFL of 10%; high-concentration 66% / 100% devices are not recommended).
See also:
https://h2-papers.org/en/papers/20568549