水素分子はmdxマウスにおける運動機能障害と筋変性を軽減する
Using mdx mice as a Duchenne muscular dystrophy (DMD) model, this study evaluated the effects of supersaturated hydrogen-rich water (>5 ppm). Pregnant dams received hydrogen water ad libitum from embryonic day 15.5 through weaning, after which offspring continued intake until sacrifice at 10 or 24 weeks of age. Hydrogen water suppressed the abnormal body weight gain characteristic of mdx mice and improved both spontaneous running distance and rotarod performance. Plasma creatine kinase activity was reduced at both 10 and 24 weeks. Histological analysis revealed fewer centrally nucleated muscle fibers and reduced nitrotyrosine immunostaining in gastrocnemius muscle. Additionally, a trend toward increased expression of antioxidant glutathione peroxidase 1 and anti-apoptotic Bcl-2 protein was observed in skeletal muscle at 10 weeks. These findings suggest that hydrogen-rich water may mitigate oxidative stress-driven pathology in dystrophic muscle.
Molecular hydrogen is proposed to scavenge reactive oxygen species, evidenced by reduced nitrotyrosine levels, while upregulating glutathione peroxidase 1 and the anti-apoptotic protein Bcl-2, collectively attenuating oxidative damage and cell death in dystrophic skeletal muscle.
Hydrogen-rich water is a low-risk delivery route, but the achievable systemic hydrogen dose is bounded. For clinical applications, inhalation is the most efficient route; inhalation, however, carries explosion risk, and concentration matters (empirical LFL of 10% applies to inhalation environments; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).
See also:
https://h2-papers.org/en/papers/26866650