分子状水素がウサギのステロイド誘発性骨壊死に対して示す酸化ストレス・アポトーシス抑制を介した保護効果
This animal study examined whether molecular hydrogen could reduce the occurrence of steroid-induced osteonecrosis (ON) in rabbits. Sixty rabbits were randomly allocated to a model group or a hydrogen group; the latter received intraperitoneal hydrogen injections at 10 ml/kg daily for seven days. Histopathological analysis revealed that ON incidence was markedly lower in the hydrogen group (28.6%) compared with the model group (68.0%). Immunohistochemical staining for 8-OHdG and MDA, along with TUNEL assays, demonstrated that oxidative injury, vascular injury, and apoptosis were all reduced in hydrogen-treated animals. Plasma cholesterol and triglyceride levels did not differ significantly between groups. These findings indicate that hydrogen administration suppresses oxidative and vascular damage as well as apoptotic cell death, thereby lowering the incidence of steroid-induced osteonecrosis.
Molecular hydrogen acts as a selective antioxidant, reducing oxidative damage markers (8-OHdG, MDA) and suppressing vascular injury and apoptotic cell death, collectively lowering the incidence of steroid-induced osteonecrosis in vivo.
Intravenous hydrogen-saline infusion is a clinic-only route and is not viable for everyday self-administration. For routine hydrogen intake, inhalation is the most practical route, but inhalation carries explosion risk and concentration matters (empirical LFL of 10%; high-concentration 66% / 100% devices are not recommended).
See also:
https://h2-papers.org/en/papers/28148301