腸内細菌叢による水素産生不足とパーキンソン病の病態との関連性に関する考察
Parkinson disease (PD) is associated with gut microbiota dysbiosis, although a definitive causal relationship has not been established. Intestinal microorganisms generate molecular hydrogen (H2), a biologically active gas with antioxidant, anti-apoptotic, anti-inflammatory, cytoprotective, and cell-signaling properties. This paper explores the hypothesis that reduced endogenous H2 production by intestinal bacteria may contribute to PD pathogenesis. The potential role of exogenous H2 supplementation as an investigational approach for this progressive neurodegenerative condition is also discussed, framing gut-derived H2 deficiency as a plausible mechanistic link between microbiome alterations and neurodegeneration.
Reduced H2 output from dysbiotic gut microbiota may diminish antioxidant and anti-inflammatory signaling, thereby permitting elevated oxidative stress and neuroinflammation that could contribute to the progression of Parkinson disease.
The delivery route is not clearly identifiable from this paper. For hydrogen intake, inhalation is the most efficient route; inhalation, however, carries explosion risk (empirical LFL of 10%; high-concentration devices are not recommended).
See also:
https://h2-papers.org/en/papers/29478695