中国蘇州の女子ユース女子サッカー選手における水素水長期摂取が抗酸化活性および腸内フローラに及ぼす影響
A 2-month intervention study was conducted in female youth soccer players from Suzhou, China, to examine how hydrogen-rich water consumption affects oxidative stress markers and gut microbiota. ELISA measurements showed significant reductions in serum malondialdehyde, interleukin-1, interleukin-6, and tumor necrosis factor-α, alongside increases in superoxide dismutase activity, total antioxidant capacity, and whole-blood hemoglobin. Stool sample analysis via 16S rDNA sequencing revealed that diversity indices—including shannon, sobs, ace, and chao—were initially lower in the hydrogen-rich water group but surpassed control values after the intervention period. Although baseline differences in gut flora composition existed between groups, no significant compositional shifts were detected during the trial. These findings suggest that sustained hydrogen-rich water intake may modulate gut microbiota through selective antioxidant and anti-inflammatory mechanisms in athletic populations.
Hydrogen-rich water is proposed to selectively scavenge reactive oxygen species, reducing lipid peroxidation products and pro-inflammatory cytokines (IL-1, IL-6, TNF-α) while enhancing superoxide dismutase activity and total antioxidant capacity, thereby creating conditions favorable for gut microbiota diversity.
Hydrogen-rich water is a low-risk delivery route, but the achievable systemic hydrogen dose is bounded. For clinical applications, inhalation is the most efficient route; inhalation, however, carries explosion risk, and concentration matters (empirical LFL of 10% applies to inhalation environments; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).
See also:
https://h2-papers.org/en/papers/30713665