水素リッチウォーターの急性摂取がサブマキシマル運動指標に与える影響：無作為化二重盲検プラセボ対照クロスオーバーパイロット試験
This randomized, double-blind, placebo-controlled crossover pilot study examined how acute hydrogen-rich water (HRW) consumption affects exercise performance in 19 healthy adults (4 female, mean age 23.4 ± 9.1 yr; 15 male, mean age 30.5 ± 6.8 yr). Participants underwent a graded treadmill test to exhaustion, with measurements of VO2, respiratory exchange ratio (RER), heart rate (HR), and respiratory rate (RR). HRW was delivered via hydrogen-producing tablets (5 mg H2) consumed the day before and on the day of testing. While maximal and minimal exercise indices remained unchanged, average exercising HR and RR were significantly reduced with HRW. During minutes 1–9 of the graded exercise test, HR was lower in the HRW condition (121 ± 26 bpm) compared to both placebo (126 ± 26 bpm) and baseline (124 ± 27 bpm) (p < 0.001), without meaningful changes in VO2. These findings suggest that acute HRW supplementation may favorably influence submaximal aerobic exercise performance, though further research is needed to clarify optimal dosing and the effects of long-term use.
HRW consumption reduced exercising heart rate and respiratory rate without altering VO2, suggesting a reduction in physiological strain during submaximal exercise, potentially linked to H2's antioxidant or autonomic modulatory properties.
Hydrogen-rich water is a low-risk delivery route, but the achievable systemic hydrogen dose is bounded. For clinical applications, inhalation is the most efficient route; inhalation, however, carries explosion risk, and concentration matters (empirical LFL of 10% applies to inhalation environments; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).
See also:
https://h2-papers.org/en/papers/30918832