水素分子はメタンフェタミン誘発行動感作およびマウス側坐核におけるERK-ΔFosBシグナル活性化を抑制する
Using a mouse model of methamphetamine (METH)-induced behavioral sensitization, this study examined whether hydrogen-rich saline (HRS; 10 mL/kg, i.p.) could modulate the acquisition and transfer of sensitized locomotor responses. Male C57BL/6 mice received METH at 0.1, 0.5, or 1.0 mg/kg for 7 days, followed by a 7-day transfer period and a subsequent challenge injection. HRS administered at 3-hour intervals during both periods partially suppressed behavioral sensitization at the 0.1 and 0.5 mg/kg doses. Accompanying molecular changes in the nucleus accumbens (NAc), specifically elevated phosphorylated ERK and ΔFosB levels, were also reduced by HRS. Additionally, METH-driven increases in reactive oxygen species and malondialdehyde in the NAc were attenuated, consistent with the antioxidant properties of molecular hydrogen. HRS alone produced no detectable alterations in baseline locomotor activity.
Molecular hydrogen exerts antioxidant effects by reducing reactive oxygen species and malondialdehyde accumulation in the nucleus accumbens, thereby dampening ERK phosphorylation and ΔFosB upregulation that underlie METH-induced behavioral sensitization.
Intravenous hydrogen-saline infusion is a clinic-only route and is not viable for everyday self-administration. For routine hydrogen intake, inhalation is the most practical route, but inhalation carries explosion risk and concentration matters (empirical LFL of 10%; high-concentration 66% / 100% devices are not recommended).
See also:
https://h2-papers.org/en/papers/31629777