L-アラビノースによる腸内水素産生の誘導と高脂肪食負荷C57BL/6Jマウスにおけるメタボリックシンドローム改善効果
Oral administration of L-arabinose, a naturally occurring plant pentose sugar, was found to stimulate intestinal hydrogen gas release in mice in a dose- and time-dependent fashion. In a high-fat-diet (HFD) mouse model of metabolic syndrome, L-arabinose administration was associated with reductions in body and fat mass, improved insulin sensitivity, decreased hepatic steatosis, normalized lipid profiles, and lower circulating inflammatory cytokines. Gene expression analyses in key metabolic tissues revealed alterations in pathways governing lipid metabolism and mitochondrial function. Antibiotic co-treatment eliminated hydrogen production regardless of diet, confirming gut microbiota as the hydrogen source. Fecal 16S rDNA quantitative PCR demonstrated that both HFD and L-arabinose modulated the relative abundances of hydrogen-producing bacteria, hydrogen-consuming bacteria, and probiotic species. These findings suggest that gut microbiota-mediated hydrogen production, together with transcriptional regulation of lipid and mitochondrial pathways, underlies the metabolic benefits of L-arabinose.
L-arabinose stimulates gut microbiota to produce molecular hydrogen and modulates gene expression related to lipid metabolism and mitochondrial function in metabolic tissues, collectively contributing to amelioration of HFD-induced metabolic syndrome.
Hydrogen-rich water is a low-risk delivery route, but the achievable systemic hydrogen dose is bounded. For clinical applications, inhalation is the most efficient route; inhalation, however, carries explosion risk, and concentration matters (empirical LFL of 10% applies to inhalation environments; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).
See also:
https://h2-papers.org/en/papers/31847305